Layer 1 Continuous Non-accommodating Neurogliaform Cell with slender axonal arborization (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, slender axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000776
cNAC187_L1_NGCSA_eb27dd33ff_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000776
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.48 mV
Rheobase Current Interval (0.02747, 0.02815] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0173 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 0.7638 mV
AP 1 Steady State Amplitude Change 1.1940 mV
AP 1 Amplitude 76.5184 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 4.1300 ms
AP 1 Rate of Change Peak to Trough -23.5263 mV/ms
AP 1 AHP Depth 20.6454 mV
AP2 Amplitude 75.7546 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 4.1900 ms
AP 2 Rate of Change Peak to Trough -23.0997 mV/ms
AP 2 AHP Depth 21.0332 mV
AP 1-2 Amplitude Change Percent -0.9982 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.8134 %
AP 1-2 AHP Depth Percent Change 1.8786 %
Input Resistance 607.9147 MΩ
AP 1 Delay Mean 15.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 55.4900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 40.0700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -10.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0199 %/ms
Accommodation at Steady State Mean -23.6935 %
Accommodation Rate Mean at Steady State 1283.7455 ms
ISI CV 16.1090
ISI Median 45.9100 ms
ISI Burst Mean Change 1.5087 %
Spike Rate (Strong Stimulation) 39.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.1100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.4400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.9300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2079.4100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 80.2951 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8251.43 µm2
Number of Stems 10.0
Number of Bifurcations 21.0
Number of Branches 51.0
Overall Width 132.123 µm
Overall Height 77.5708 µm
Overall Depth 94.68 µm
Average Diameter 0.980023 µm
Total Length 1427.53 µm
Total Surface 4184.6 µm2
Total Volume 3283.31 µm3
Max Euclidean Distance 124.935 µm
Max Path Distance 171.732 µm
Max Branch Order 6.0
Average Contraction 0.924428
Total Fragmentation 1005.0
Partition Asymmetry 0.427664
Average Rall's Ratio 0.553235
Average Bifurcation Angle Local 16.3789 °
Average Bifurcation Angle Remote 81.8494 °
Fractal Dimension 1.01284
Complexity Summary
State Equations 781
Optimal Time-Step 0.00788 ms
Relative Complexity 184.12 HH
Model Size
Sections 52
Compartments 76
State Equations 781
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00788 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 184.12 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.67 %
Max. Stable Time-Step Benchmark Run Time 362.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13309 Hz
CVODE Steps Per AP 530
CVODE Benchmark Run Time 177.49 HH
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