Layer 1 Continuous Non-accommodating Neurogliaform Cell with dense axonal arborization (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000771
cNAC187_L1_NGCDA_cef6c2b159_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000771
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.63 mV
Rheobase Current Interval (0.02335, 0.02380] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0143 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 0.4468 mV
AP 1 Steady State Amplitude Change 2.0511 mV
AP 1 Amplitude 79.7338 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.7500 ms
AP 1 Rate of Change Peak to Trough -38.7403 mV/ms
AP 1 AHP Depth 26.8019 mV
AP2 Amplitude 79.2871 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 2.7300 ms
AP 2 Rate of Change Peak to Trough -38.7194 mV/ms
AP 2 AHP Depth 26.4168 mV
AP 1-2 Amplitude Change Percent -0.5603 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0539 %
AP 1-2 AHP Depth Percent Change -1.4368 %
Input Resistance 723.9636 MΩ
AP 1 Delay Mean 11.3300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 46.0000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 35.0950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -27.2727 %
Steady State Accommodation Mean -27.2727 %
Accommodation Rate to Steady State -0.0247 %/ms
Accommodation at Steady State Mean -40.6204 %
Accommodation Rate Mean at Steady State 919.4453 ms
ISI CV 7.6142
ISI Median 47.7700 ms
ISI Burst Mean Change 2.4517 %
Spike Rate (Strong Stimulation) 38.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.6500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 24.8600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.8200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2104.5100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 71.2815 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7365.25 µm2
Number of Stems 7.0
Number of Bifurcations 13.0
Number of Branches 32.0
Overall Width 65.595 µm
Overall Height 94.396 µm
Overall Depth 49.47 µm
Average Diameter 1.63888 µm
Total Length 637.457 µm
Total Surface 2511.75 µm2
Total Volume 2382.05 µm3
Max Euclidean Distance 84.6168 µm
Max Path Distance 105.28 µm
Max Branch Order 3.0
Average Contraction 0.950993
Total Fragmentation 336.0
Partition Asymmetry 0.346154
Average Rall's Ratio 1.82056
Average Bifurcation Angle Local 38.7568 °
Average Bifurcation Angle Remote 85.7623 °
Fractal Dimension 1.00631
Complexity Summary
State Equations 391
Optimal Time-Step 0.00779 ms
Relative Complexity 86.12 HH
Model Size
Sections 33
Compartments 37
State Equations 391
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.34 %
Optimal Time-Step Benchmark Run Time 86.12 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.07 %
Max. Stable Time-Step Benchmark Run Time 167.67 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14038 Hz
CVODE Steps Per AP 459
CVODE Benchmark Run Time 82.19 HH
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