Layer 1 Continuous Non-accommodating Neurogliaform Cell with dense axonal arborization (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000768
cNAC187_L1_NGCDA_886ddf503d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000768
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.11 mV
Rheobase Current Interval (0.00778, 0.00824] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0094 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop -0.2856 mV
AP 1 Steady State Amplitude Change -0.2677 mV
AP 1 Amplitude 73.1758 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 5.0100 ms
AP 1 Rate of Change Peak to Trough -19.5644 mV/ms
AP 1 AHP Depth 24.8421 mV
AP2 Amplitude 73.4614 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 5.1400 ms
AP 2 Rate of Change Peak to Trough -19.0419 mV/ms
AP 2 AHP Depth 24.4138 mV
AP 1-2 Amplitude Change Percent 0.3903 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.6710 %
AP 1-2 AHP Depth Percent Change -1.7239 %
Input Resistance 1108.9728 MΩ
AP 1 Delay Mean 32.0600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 94.8500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 63.1950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.0146 %/ms
Accommodation at Steady State Mean -26.9164 %
Accommodation Rate Mean at Steady State 1221.3459 ms
ISI CV 13.6021
ISI Median 73.8850 ms
ISI Burst Mean Change 1.2900 %
Spike Rate (Strong Stimulation) 26.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.0000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 45.2600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 33.5300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2147.7200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 105.6399 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1958.43 µm2
Number of Stems 7.0
Number of Bifurcations 29.0
Number of Branches 64.0
Overall Width 117.172 µm
Overall Height 140.32 µm
Overall Depth 67.8 µm
Average Diameter 0.480358 µm
Total Length 1536.9 µm
Total Surface 2422.29 µm2
Total Volume 901.793 µm3
Max Euclidean Distance 110.53 µm
Max Path Distance 140.068 µm
Max Branch Order 6.0
Average Contraction 0.936533
Total Fragmentation 1566.0
Partition Asymmetry 0.476348
Average Rall's Ratio 1.08587
Average Bifurcation Angle Local 38.6559 °
Average Bifurcation Angle Remote 70.0903 °
Fractal Dimension 1.01355
Complexity Summary
State Equations 931
Optimal Time-Step 0.00777 ms
Relative Complexity 201.77 HH
Model Size
Sections 65
Compartments 91
State Equations 931
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 201.77 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.62 %
Max. Stable Time-Step Benchmark Run Time 392.00 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15441 Hz
CVODE Steps Per AP 448
CVODE Benchmark Run Time 205.41 HH
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