Layer 1 Continuous Non-accommodating Horizontal Axon Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon, biophysical, continuous non-accommodating horizontal axon cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000763
cNAC187_L1_HAC_cc210b8244_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000763
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.28 mV
Rheobase Current Interval (0.01854, 0.01923] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0156 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.5226 mV
AP 1 Steady State Amplitude Change 2.1090 mV
AP 1 Amplitude 63.7143 mV
AP 1 Width at Half Height 0.8400 ms
AP 1 Width (Peak To Trough) 6.4300 ms
AP 1 Rate of Change Peak to Trough -12.7125 mV/ms
AP 1 AHP Depth 18.0268 mV
AP2 Amplitude 63.1917 mV
AP2 Width at Half Height 0.8500 ms
AP 2 Width (Peak to Trough) 6.5100 ms
AP 2 Rate of Change Peak to Trough -12.4569 mV/ms
AP 2 AHP Depth 17.9025 mV
AP 1-2 Amplitude Change Percent -0.8203 %
AP 1-2 Half Width Change Percent 1.1905 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.0105 %
AP 1-2 AHP Depth Percent Change -0.6893 %
Input Resistance 680.5776 MΩ
AP 1 Delay Mean 23.8200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 74.7900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.2900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -12.5000 %
Steady State Accommodation Mean -12.5000 %
Accommodation Rate to Steady State -0.0124 %/ms
Accommodation at Steady State Mean -22.4926 %
Accommodation Rate Mean at Steady State 1361.8700 ms
ISI CV 17.4126
ISI Median 57.9300 ms
ISI Burst Mean Change 1.2556 %
Spike Rate (Strong Stimulation) 33.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.1100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 36.6000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.9700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2094.3600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 125.4753 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5680.93 µm2
Number of Stems 5.0
Number of Bifurcations 21.0
Number of Branches 46.0
Overall Width 148.035 µm
Overall Height 173.446 µm
Overall Depth 77.22 µm
Average Diameter 0.799549 µm
Total Length 1920.61 µm
Total Surface 4229.99 µm2
Total Volume 2145.11 µm3
Max Euclidean Distance 155.394 µm
Max Path Distance 193.413 µm
Max Branch Order 6.0
Average Contraction 0.941089
Total Fragmentation 1124.0
Partition Asymmetry 0.464701
Average Rall's Ratio 1.53125
Average Bifurcation Angle Local 43.9417 °
Average Bifurcation Angle Remote 83.6087 °
Fractal Dimension 1.01121
Complexity Summary
Relative Complexity 225.09 HH
State Equations 1031
Optimal Time-Step 0.00773 ms
Model Size
Sections 47
Compartments 101
State Equations 1031
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15058 Hz
CVODE Steps Per AP 450
CVODE Benchmark Run Time 225.09 HH
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