Layer 1 Continuous Non-accommodating Large Axon Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, large axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000761
cNAC187_L1_DLAC_d80e9f2875_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000761
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.05 mV
Rheobase Current Interval (0.01373, 0.01442] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0149 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.4374 mV
AP 1 Steady State Amplitude Change 0.3968 mV
AP 1 Amplitude 63.4308 mV
AP 1 Width at Half Height 0.8900 ms
AP 1 Width (Peak To Trough) 7.4600 ms
AP 1 Rate of Change Peak to Trough -11.1905 mV/ms
AP 1 AHP Depth 20.0506 mV
AP2 Amplitude 62.9934 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 7.5000 ms
AP 2 Rate of Change Peak to Trough -11.1158 mV/ms
AP 2 AHP Depth 20.3755 mV
AP 1-2 Amplitude Change Percent -0.6896 %
AP 1-2 Half Width Change Percent -1.1236 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.6674 %
AP 1-2 AHP Depth Percent Change 1.6203 %
Input Resistance 736.3333 MΩ
AP 1 Delay Mean 40.9900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 113.4600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 72.8150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -19.3380 %
Accommodation Rate Mean at Steady State 1292.7239 ms
ISI CV 20.2347
ISI Median 80.7500 ms
ISI Burst Mean Change 0.9521 %
Spike Rate (Strong Stimulation) 25.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 50.8500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 36.3150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2118.0300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 82.9286 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4027.82 µm2
Number of Stems 7.0
Number of Bifurcations 24.0
Number of Branches 54.0
Overall Width 119.007 µm
Overall Height 179.845 µm
Overall Depth 72.43 µm
Average Diameter 0.783566 µm
Total Length 2075.38 µm
Total Surface 4812.4 µm2
Total Volume 1958.72 µm3
Max Euclidean Distance 156.646 µm
Max Path Distance 196.805 µm
Max Branch Order 5.0
Average Contraction 0.934784
Total Fragmentation 1428.0
Partition Asymmetry 0.473611
Average Rall's Ratio 1.50361
Average Bifurcation Angle Local 41.5071 °
Average Bifurcation Angle Remote 63.1084 °
Fractal Dimension 1.01216
Complexity Summary
State Equations 1071
Optimal Time-Step 0.00777 ms
Relative Complexity 241.72 HH
Model Size
Sections 55
Compartments 105
State Equations 1071
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 241.72 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.92 %
Max. Stable Time-Step Benchmark Run Time 469.63 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14820 Hz
CVODE Steps Per AP 496
CVODE Benchmark Run Time 244.35 HH
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