Layer 1 Continuous Non-accommodating Large Axon Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, large axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000759
cNAC187_L1_DLAC_612b4ae64f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000759
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.28 mV
Rheobase Current Interval (0.02403, 0.02472] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0180 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.1756 mV
AP 1 Steady State Amplitude Change 0.6559 mV
AP 1 Amplitude 69.0622 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 5.5200 ms
AP 1 Rate of Change Peak to Trough -16.4740 mV/ms
AP 1 AHP Depth 21.8744 mV
AP2 Amplitude 68.8866 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 5.6400 ms
AP 2 Rate of Change Peak to Trough -16.0959 mV/ms
AP 2 AHP Depth 21.8941 mV
AP 1-2 Amplitude Change Percent -0.2542 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.2954 %
AP 1-2 AHP Depth Percent Change 0.0901 %
Input Resistance 596.7137 MΩ
AP 1 Delay Mean 22.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 71.6900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 49.2400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -12.5000 %
Steady State Accommodation Mean -12.5000 %
Accommodation Rate to Steady State -0.0123 %/ms
Accommodation at Steady State Mean -21.2389 %
Accommodation Rate Mean at Steady State 1283.4755 ms
ISI CV 18.1307
ISI Median 55.5200 ms
ISI Burst Mean Change 1.1027 %
Spike Rate (Strong Stimulation) 33.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.9400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 35.7100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.2400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2073.1800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.3966 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6946.92 µm2
Number of Stems 7.0
Number of Bifurcations 41.0
Number of Branches 88.0
Overall Width 156.738 µm
Overall Height 148.052 µm
Overall Depth 81.85 µm
Average Diameter 0.656519 µm
Total Length 2578.58 µm
Total Surface 5238.45 µm2
Total Volume 2868.93 µm3
Max Euclidean Distance 149.817 µm
Max Path Distance 230.286 µm
Max Branch Order 6.0
Average Contraction 0.934498
Total Fragmentation 2476.0
Partition Asymmetry 0.43219
Average Rall's Ratio 1.13766
Average Bifurcation Angle Local 33.9214 °
Average Bifurcation Angle Remote 78.1207 °
Fractal Dimension 1.01542
Complexity Summary
State Equations 1451
Optimal Time-Step 0.00768 ms
Relative Complexity 346.01 HH
Model Size
Sections 89
Compartments 143
State Equations 1451
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.33 %
Optimal Time-Step Benchmark Run Time 346.01 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.49 %
Max. Stable Time-Step Benchmark Run Time 663.85 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13467 Hz
CVODE Steps Per AP 648
CVODE Benchmark Run Time 348.34 HH
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