Layer 1 Continuous Non-accommodating Descending Axon Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000756
cNAC187_L1_DAC_a4cb1c245c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000756
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.08 mV
Rheobase Current Interval (0.01511, 0.01579] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0151 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.3588 mV
AP 1 Steady State Amplitude Change 0.7441 mV
AP 1 Amplitude 63.7672 mV
AP 1 Width at Half Height 0.8500 ms
AP 1 Width (Peak To Trough) 7.1100 ms
AP 1 Rate of Change Peak to Trough -11.3943 mV/ms
AP 1 AHP Depth 17.2463 mV
AP2 Amplitude 63.4084 mV
AP2 Width at Half Height 0.8500 ms
AP 2 Width (Peak to Trough) 7.1700 ms
AP 2 Rate of Change Peak to Trough -11.2696 mV/ms
AP 2 AHP Depth 17.3947 mV
AP 1-2 Amplitude Change Percent -0.5627 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.0944 %
AP 1-2 AHP Depth Percent Change 0.8603 %
Input Resistance 724.0426 MΩ
AP 1 Delay Mean 30.4300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 89.6900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.5500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -14.2857 %
Steady State Accommodation Mean -14.2857 %
Accommodation Rate to Steady State -0.0147 %/ms
Accommodation at Steady State Mean -18.9533 %
Accommodation Rate Mean at Steady State 1320.8999 ms
ISI CV 20.8311
ISI Median 65.9600 ms
ISI Burst Mean Change 0.9787 %
Spike Rate (Strong Stimulation) 30.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.4000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 42.1900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.2600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2115.2700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 119.3529 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4480.71 µm2
Number of Stems 8.0
Number of Bifurcations 19.0
Number of Branches 45.0
Overall Width 269.458 µm
Overall Height 280.099 µm
Overall Depth 143.67 µm
Average Diameter 0.744714 µm
Total Length 2170.92 µm
Total Surface 4567.46 µm2
Total Volume 1928.73 µm3
Max Euclidean Distance 253.191 µm
Max Path Distance 282.283 µm
Max Branch Order 5.0
Average Contraction 0.941726
Total Fragmentation 1153.0
Partition Asymmetry 0.517544
Average Rall's Ratio 2.07944
Average Bifurcation Angle Local 39.657 °
Average Bifurcation Angle Remote 82.8549 °
Fractal Dimension 1.01161
Complexity Summary
State Equations 1171
Optimal Time-Step 0.00769 ms
Relative Complexity 274.24 HH
Model Size
Sections 47
Compartments 115
State Equations 1171
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 274.24 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.29 %
Max. Stable Time-Step Benchmark Run Time 527.16 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14720 Hz
CVODE Steps Per AP 546
CVODE Benchmark Run Time 279.84 HH
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