Layer 1 Continuous Non-accommodating Descending Axon Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, biophysical, continuous non-accommodating descending axon cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000754
cNAC187_L1_DAC_81e928d216_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000754
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.68 mV
Rheobase Current Interval (0.01030, 0.01099] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0158 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop -0.2881 mV
AP 1 Steady State Amplitude Change -0.1462 mV
AP 1 Amplitude 62.5508 mV
AP 1 Width at Half Height 0.8800 ms
AP 1 Width (Peak To Trough) 10.1800 ms
AP 1 Rate of Change Peak to Trough -7.8691 mV/ms
AP 1 AHP Depth 17.5562 mV
AP2 Amplitude 62.8389 mV
AP2 Width at Half Height 0.8900 ms
AP 2 Width (Peak to Trough) 10.1700 ms
AP 2 Rate of Change Peak to Trough -7.8677 mV/ms
AP 2 AHP Depth 17.1760 mV
AP 1-2 Amplitude Change Percent 0.4606 %
AP 1-2 Half Width Change Percent 1.1364 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0167 %
AP 1-2 AHP Depth Percent Change -2.1654 %
Input Resistance 736.3609 MΩ
AP 1 Delay Mean 60.4300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 155.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 95.0200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -14.5193 %
Accommodation Rate Mean at Steady State 1389.2237 ms
ISI CV 28.4276
ISI Median 101.9700 ms
ISI Burst Mean Change 0.9092 %
Spike Rate (Strong Stimulation) 21.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 21.8100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 66.1600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 44.6650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2133.9200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 53.6396 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3038.57 µm2
Number of Stems 8.0
Number of Bifurcations 30.0
Number of Branches 67.0
Overall Width 196.107 µm
Overall Height 200.421 µm
Overall Depth 144.19 µm
Average Diameter 0.65489 µm
Total Length 3020.43 µm
Total Surface 5595.91 µm2
Total Volume 1890.61 µm3
Max Euclidean Distance 205.809 µm
Max Path Distance 231.609 µm
Max Branch Order 7.0
Average Contraction 0.946447
Total Fragmentation 1680.0
Partition Asymmetry 0.444545
Average Rall's Ratio 1.20889
Average Bifurcation Angle Local 38.191 °
Average Bifurcation Angle Remote 73.37 °
Fractal Dimension 1.00931
Complexity Summary
Relative Complexity 356.68 HH
State Equations 1581
Optimal Time-Step 0.00780 ms
Model Size
Sections 68
Compartments 156
State Equations 1581
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15383 Hz
CVODE Steps Per AP 362
CVODE Benchmark Run Time 356.68 HH
Website & Images Copyright NeuroML © 2024 For questions: Contact us Links: Search Test |  ModelDB WS