Layer 1 Continuous Non-accommodating Descending Axon Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000753
cNAC187_L1_DAC_2e9c9967f8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000753
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.92 mV
Rheobase Current Interval (0.04120, 0.04211] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0308 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.2278 mV
AP 1 Steady State Amplitude Change 0.5427 mV
AP 1 Amplitude 77.0061 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.9300 ms
AP 1 Rate of Change Peak to Trough -33.4744 mV/ms
AP 1 AHP Depth 21.0739 mV
AP2 Amplitude 76.7783 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 2.9900 ms
AP 2 Rate of Change Peak to Trough -32.7283 mV/ms
AP 2 AHP Depth 21.0793 mV
AP 1-2 Amplitude Change Percent -0.2959 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.2289 %
AP 1-2 AHP Depth Percent Change 0.0258 %
Input Resistance 362.4612 MΩ
AP 1 Delay Mean 17.4800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 59.5600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 42.4300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -11.1111 %
Accommodation Rate to Steady State -0.0122 %/ms
Accommodation at Steady State Mean -18.3938 %
Accommodation Rate Mean at Steady State 1342.7781 ms
ISI CV 21.8620
ISI Median 46.9200 ms
ISI Burst Mean Change 1.6635 %
Spike Rate (Strong Stimulation) 39.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.6200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.2500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2066.9600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.4067 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 12892.4 µm2
Number of Stems 4.0
Number of Bifurcations 13.0
Number of Branches 29.0
Overall Width 295.314 µm
Overall Height 465.5 µm
Overall Depth 166.94 µm
Average Diameter 1.14454 µm
Total Length 2159.46 µm
Total Surface 7238.05 µm2
Total Volume 5374.21 µm3
Max Euclidean Distance 356.63 µm
Max Path Distance 477.518 µm
Max Branch Order 5.0
Average Contraction 0.924306
Total Fragmentation 1043.0
Partition Asymmetry 0.579487
Average Rall's Ratio 1.71667
Average Bifurcation Angle Local 18.6861 °
Average Bifurcation Angle Remote 69.4257 °
Fractal Dimension 1.0107
Complexity Summary
State Equations 1101
Optimal Time-Step 0.00765 ms
Relative Complexity 269.50 HH
Model Size
Sections 30
Compartments 108
State Equations 1101
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00765 ms
Optimal Time-Step Error 0.36 %
Optimal Time-Step Benchmark Run Time 269.50 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.70 %
Max. Stable Time-Step Benchmark Run Time 514.98 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13402 Hz
CVODE Steps Per AP 495
CVODE Benchmark Run Time 248.69 HH
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