Layer 6 Continuous Irregular Nest Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000750
cIR216_L6_NBC_656e1c0a2d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000750
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.05 mV
Rheobase Current Interval (0.13550, 0.13733] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -70.00 mV) 0.0355 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.9518 mV
AP 1 Steady State Amplitude Change 7.7088 mV
AP 1 Amplitude 87.3100 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 2.3700 ms
AP 1 Rate of Change Peak to Trough -42.7964 mV/ms
AP 1 AHP Depth 14.1176 mV
AP2 Amplitude 83.3581 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 2.4200 ms
AP 2 Rate of Change Peak to Trough -41.0424 mV/ms
AP 2 AHP Depth 15.9644 mV
AP 1-2 Amplitude Change Percent -4.5262 %
AP 1-2 Half Width Change Percent -4.9180 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.0986 %
AP 1-2 AHP Depth Percent Change 13.0819 %
Input Resistance 263.7808 MΩ
AP 1 Delay Mean 11.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.7900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 17.3500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -38.4615 %
Steady State Accommodation Mean -38.4615 %
Accommodation Rate to Steady State -0.1355 %/ms
Accommodation at Steady State Mean -77.5543 %
Accommodation Rate Mean at Steady State 160.2406 ms
ISI CV 4.2191
ISI Median 49.6350 ms
ISI Burst Mean Change 20.4574 %
Spike Rate (Strong Stimulation) 41.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.3600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.7900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.9900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2021.5400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 96.3715 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6007.87 µm2
Number of Stems 7.0
Number of Bifurcations 27.0
Number of Branches 60.0
Overall Width 420.863 µm
Overall Height 658.182 µm
Overall Depth 343.31 µm
Average Diameter 0.912917 µm
Total Length 4637.37 µm
Total Surface 12088.1 µm2
Total Volume 4056.29 µm3
Max Euclidean Distance 515.293 µm
Max Path Distance 541.307 µm
Max Branch Order 4.0
Average Contraction 0.979943
Total Fragmentation 1218.0
Partition Asymmetry 0.380658
Average Rall's Ratio 0.937857
Average Bifurcation Angle Local 41.7149 °
Average Bifurcation Angle Remote 48.46 °
Fractal Dimension 1.00312
Complexity Summary
State Equations 2538
Optimal Time-Step 0.00774 ms
Relative Complexity 658.11 HH
Model Size
Sections 61
Compartments 229
State Equations 2538
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 658.11 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.65 %
Max. Stable Time-Step Benchmark Run Time 1273.04 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17465 Hz
CVODE Steps Per AP 229
CVODE Benchmark Run Time 661.62 HH
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