Layer 6 Continuous Irregular Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, continuous irregular nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000747
cIR216_L6_NBC_0546dde601_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000747
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.43 mV
Rheobase Current Interval (0.11375, 0.11536] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0280 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 2.7295 mV
AP 1 Steady State Amplitude Change 6.3303 mV
AP 1 Amplitude 89.9917 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 2.4000 ms
AP 1 Rate of Change Peak to Trough -45.0488 mV/ms
AP 1 AHP Depth 18.1254 mV
AP2 Amplitude 87.2622 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.4500 ms
AP 2 Rate of Change Peak to Trough -43.7118 mV/ms
AP 2 AHP Depth 19.8318 mV
AP 1-2 Amplitude Change Percent -3.0331 %
AP 1-2 Half Width Change Percent -3.3898 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.9678 %
AP 1-2 AHP Depth Percent Change 9.4144 %
Input Resistance 368.6882 MΩ
AP 1 Delay Mean 9.6000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.8400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 16.8850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -30.0000 %
Accommodation Rate to Steady State -0.1392 %/ms
Accommodation at Steady State Mean -86.9615 %
Accommodation Rate Mean at Steady State 125.0772 ms
ISI CV 3.6965
ISI Median 63.3500 ms
ISI Burst Mean Change 21.5879 %
Spike Rate (Strong Stimulation) 34.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.4300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.3300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.3700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.3200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 121.0277 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9113.12 µm2
Number of Stems 5.0
Number of Bifurcations 29.0
Number of Branches 62.0
Overall Width 440.604 µm
Overall Height 675.234 µm
Overall Depth 386.1 µm
Average Diameter 0.681573 µm
Total Length 5569.82 µm
Total Surface 8244.64 µm2
Total Volume 3815.6 µm3
Max Euclidean Distance 638.667 µm
Max Path Distance 670.603 µm
Max Branch Order 7.0
Average Contraction 0.981124
Total Fragmentation 1184.0
Partition Asymmetry 0.580172
Average Rall's Ratio 1.11167
Average Bifurcation Angle Local 27.276 °
Average Bifurcation Angle Remote 47.4339 °
Fractal Dimension 1.0025
Complexity Summary
Relative Complexity 818.34 HH
State Equations 3066
Optimal Time-Step 0.00766 ms
Model Size
Sections 63
Compartments 277
State Equations 3066
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17747 Hz
CVODE Steps Per AP 292
CVODE Benchmark Run Time 818.34 HH
Website & Images Copyright NeuroML © 2024 For questions: Contact us Links: Search Test |  ModelDB WS