Layer 6 Continuous Irregular Martinotti Cell (3)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000744
cIR216_L6_MC_a405be0ec4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000744
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.79 mV
Rheobase Current Interval (0.14214, 0.14420] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.0331 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 6.8297 mV
AP 1 Steady State Amplitude Change 14.8950 mV
AP 1 Amplitude 84.6437 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.2500 ms
AP 1 Rate of Change Peak to Trough -28.1828 mV/ms
AP 1 AHP Depth 6.9505 mV
AP2 Amplitude 77.8140 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.4300 ms
AP 2 Rate of Change Peak to Trough -25.4669 mV/ms
AP 2 AHP Depth 9.5374 mV
AP 1-2 Amplitude Change Percent -8.0687 %
AP 1-2 Half Width Change Percent -1.5385 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.6369 %
AP 1-2 AHP Depth Percent Change 37.2191 %
Input Resistance 295.7977 MΩ
AP 1 Delay Mean 9.2700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.3550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1598 %/ms
Accommodation at Steady State Mean -82.0471 %
Accommodation Rate Mean at Steady State 110.5998 ms
ISI CV 4.3123
ISI Median 47.4950 ms
ISI Burst Mean Change 23.3455 %
Spike Rate (Strong Stimulation) 45.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.5800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.1700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.9900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2088.4400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 123.0777 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6342.27 µm2
Number of Stems 7.0
Number of Bifurcations 26.0
Number of Branches 58.0
Overall Width 303.832 µm
Overall Height 429.282 µm
Overall Depth 199.43 µm
Average Diameter 0.649388 µm
Total Length 5014.22 µm
Total Surface 9954.27 µm2
Total Volume 3252.9 µm3
Max Euclidean Distance 351.89 µm
Max Path Distance 362.706 µm
Max Branch Order 6.0
Average Contraction 0.968827
Total Fragmentation 3497.0
Partition Asymmetry 0.384615
Average Rall's Ratio 1.29857
Average Bifurcation Angle Local 35.8565 °
Average Bifurcation Angle Remote 50.1183 °
Fractal Dimension 1.00548
Complexity Summary
State Equations 2758
Optimal Time-Step 0.00540 ms
Relative Complexity 969.99 HH
Model Size
Sections 59
Compartments 249
State Equations 2758
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00540 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 969.99 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.07 %
Max. Stable Time-Step Benchmark Run Time 2615.82 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19277 Hz
CVODE Steps Per AP 97
CVODE Benchmark Run Time 696.71 HH
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