Layer 6 Continuous Irregular Martinotti Cell (2)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000743
cIR216_L6_MC_8f96a2b924_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000743
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.81 mV
Rheobase Current Interval (0.14008, 0.14214] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.0328 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 6.4118 mV
AP 1 Steady State Amplitude Change 14.5495 mV
AP 1 Amplitude 84.4527 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.2900 ms
AP 1 Rate of Change Peak to Trough -27.7593 mV/ms
AP 1 AHP Depth 6.8754 mV
AP2 Amplitude 78.0409 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.4800 ms
AP 2 Rate of Change Peak to Trough -25.1444 mV/ms
AP 2 AHP Depth 9.4617 mV
AP 1-2 Amplitude Change Percent -7.5921 %
AP 1-2 Half Width Change Percent -1.5385 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.4197 %
AP 1-2 AHP Depth Percent Change 37.6171 %
Input Resistance 300.0493 MΩ
AP 1 Delay Mean 9.3800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.3200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.5500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1568 %/ms
Accommodation at Steady State Mean -82.0461 %
Accommodation Rate Mean at Steady State 110.9363 ms
ISI CV 4.3236
ISI Median 48.0250 ms
ISI Burst Mean Change 23.0990 %
Spike Rate (Strong Stimulation) 44.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.6400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.2900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.0650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2096.3600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 101.8217 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6342.27 µm2
Number of Stems 7.0
Number of Bifurcations 26.0
Number of Branches 58.0
Overall Width 304.254 µm
Overall Height 416.504 µm
Overall Depth 199.44 µm
Average Diameter 0.649388 µm
Total Length 4952.01 µm
Total Surface 9837.97 µm2
Total Volume 3230.8 µm3
Max Euclidean Distance 343.675 µm
Max Path Distance 354.73 µm
Max Branch Order 6.0
Average Contraction 0.968428
Total Fragmentation 3497.0
Partition Asymmetry 0.384615
Average Rall's Ratio 1.29857
Average Bifurcation Angle Local 31.8456 °
Average Bifurcation Angle Remote 50.532 °
Fractal Dimension 1.00556
Complexity Summary
State Equations 2714
Optimal Time-Step 0.00538 ms
Relative Complexity 945.38 HH
Model Size
Sections 59
Compartments 245
State Equations 2714
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00538 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 945.38 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.96 %
Max. Stable Time-Step Benchmark Run Time 2543.11 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18805 Hz
CVODE Steps Per AP 140
CVODE Benchmark Run Time 675.91 HH
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