Layer 6 Continuous Irregular Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000742
cIR216_L6_MC_87e499e11e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000742
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.46 mV
Rheobase Current Interval (0.15221, 0.15381] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0392 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 4.0802 mV
AP 1 Steady State Amplitude Change 10.1881 mV
AP 1 Amplitude 87.1666 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 2.3900 ms
AP 1 Rate of Change Peak to Trough -41.6557 mV/ms
AP 1 AHP Depth 12.3904 mV
AP2 Amplitude 83.0864 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 2.3600 ms
AP 2 Rate of Change Peak to Trough -41.2295 mV/ms
AP 2 AHP Depth 14.2154 mV
AP 1-2 Amplitude Change Percent -4.6810 %
AP 1-2 Half Width Change Percent -3.2787 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.0230 %
AP 1-2 AHP Depth Percent Change 14.7286 %
Input Resistance 209.5479 MΩ
AP 1 Delay Mean 9.0700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 21.6400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 14.3700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1349 %/ms
Accommodation at Steady State Mean -84.5503 %
Accommodation Rate Mean at Steady State 121.8157 ms
ISI CV 4.0080
ISI Median 49.6800 ms
ISI Burst Mean Change 28.6396 %
Spike Rate (Strong Stimulation) 46.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.5100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.6600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.3850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2021.7200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 103.5468 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6045.57 µm2
Number of Stems 4.0
Number of Bifurcations 78.0
Number of Branches 159.0
Overall Width 364.353 µm
Overall Height 894.977 µm
Overall Depth 221.71 µm
Average Diameter 0.738131 µm
Total Length 6914.6 µm
Total Surface 15419.0 µm2
Total Volume 5489.13 µm3
Max Euclidean Distance 533.996 µm
Max Path Distance 610.97 µm
Max Branch Order 11.0
Average Contraction 0.93785
Total Fragmentation 8365.0
Partition Asymmetry 0.588923
Average Rall's Ratio 0.839914
Average Bifurcation Angle Local 29.1686 °
Average Bifurcation Angle Remote 71.91 °
Fractal Dimension 1.01422
Complexity Summary
State Equations 4210
Optimal Time-Step 0.00544 ms
Relative Complexity 1575.51 HH
Model Size
Sections 159
Compartments 381
State Equations 4210
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00544 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 1575.51 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.85 %
Max. Stable Time-Step Benchmark Run Time 4284.00 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19106 Hz
CVODE Steps Per AP 247
CVODE Benchmark Run Time 1215.89 HH
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