Layer 6 Continuous Irregular Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000741
cIR216_L6_DBC_f7446db64e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000741
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.39 mV
Rheobase Current Interval (0.10574, 0.10712] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0268 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 5.9247 mV
AP 1 Steady State Amplitude Change 11.2573 mV
AP 1 Amplitude 84.3966 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 3.0000 ms
AP 1 Rate of Change Peak to Trough -31.7862 mV/ms
AP 1 AHP Depth 10.9621 mV
AP2 Amplitude 78.4719 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 3.1200 ms
AP 2 Rate of Change Peak to Trough -29.5437 mV/ms
AP 2 AHP Depth 13.7045 mV
AP 1-2 Amplitude Change Percent -7.0201 %
AP 1-2 Half Width Change Percent -1.4925 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.0549 %
AP 1-2 AHP Depth Percent Change 25.0178 %
Input Resistance 367.7244 MΩ
AP 1 Delay Mean 9.5700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.7600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.8500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -36.3636 %
Accommodation Rate to Steady State -0.1707 %/ms
Accommodation at Steady State Mean -86.7350 %
Accommodation Rate Mean at Steady State 103.9015 ms
ISI CV 3.9378
ISI Median 56.9500 ms
ISI Burst Mean Change 23.3968 %
Spike Rate (Strong Stimulation) 44.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.5500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.3000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.0000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2031.9600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 116.8993 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5585.64 µm2
Number of Stems 3.0
Number of Bifurcations 22.0
Number of Branches 46.0
Overall Width 437.29 µm
Overall Height 579.786 µm
Overall Depth 365.07 µm
Average Diameter 0.65959 µm
Total Length 4469.9 µm
Total Surface 8709.77 µm2
Total Volume 3319.27 µm3
Max Euclidean Distance 361.858 µm
Max Path Distance 509.468 µm
Max Branch Order 7.0
Average Contraction 0.940333
Total Fragmentation 2409.0
Partition Asymmetry 0.445776
Average Rall's Ratio 1.26533
Average Bifurcation Angle Local 25.7998 °
Average Bifurcation Angle Remote 68.6818 °
Fractal Dimension 1.01158
Complexity Summary
State Equations 2560
Optimal Time-Step 0.00543 ms
Relative Complexity 892.31 HH
Model Size
Sections 47
Compartments 231
State Equations 2560
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 892.31 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 2421.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19091 Hz
CVODE Steps Per AP 263
CVODE Benchmark Run Time 692.00 HH
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