Layer 6 Continuous Irregular Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000739
cIR216_L6_DBC_9e6b867e51_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000739
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.86 mV
Rheobase Current Interval (0.15358, 0.15610] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -70.00 mV) 0.0376 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 3.9313 mV
AP 1 Steady State Amplitude Change 8.7722 mV
AP 1 Amplitude 81.7239 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 3.9900 ms
AP 1 Rate of Change Peak to Trough -23.7123 mV/ms
AP 1 AHP Depth 12.8884 mV
AP2 Amplitude 77.7925 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 4.2400 ms
AP 2 Rate of Change Peak to Trough -21.9359 mV/ms
AP 2 AHP Depth 15.2158 mV
AP 1-2 Amplitude Change Percent -4.8105 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.4915 %
AP 1-2 AHP Depth Percent Change 18.0585 %
Input Resistance 277.8709 MΩ
AP 1 Delay Mean 11.1400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 28.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.0150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -45.4545 %
Accommodation Rate to Steady State -0.1675 %/ms
Accommodation at Steady State Mean -82.3773 %
Accommodation Rate Mean at Steady State 130.2245 ms
ISI CV 3.9391
ISI Median 59.0500 ms
ISI Burst Mean Change 16.2024 %
Spike Rate (Strong Stimulation) 35.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.5400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.4150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2034.5200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.4653 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 171.578 µm
Overall Height 389.58 µm
Overall Depth 136.93 µm
Average Diameter 1.43863 µm
Total Length 2624.77 µm
Total Surface 10793.1 µm2
Total Volume 6183.84 µm3
Max Euclidean Distance 241.537 µm
Max Path Distance 278.194 µm
Max Branch Order 6.0
Average Contraction 0.976499
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 23.4604 °
Average Bifurcation Angle Remote 42.558 °
Fractal Dimension 1.0031
Complexity Summary
State Equations 1416
Optimal Time-Step 0.00753 ms
Relative Complexity 355.10 HH
Model Size
Sections 63
Compartments 127
State Equations 1416
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00753 ms
Optimal Time-Step Error 0.58 %
Optimal Time-Step Benchmark Run Time 355.10 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 3.07 %
Max. Stable Time-Step Benchmark Run Time 668.16 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13972 Hz
CVODE Steps Per AP 283
CVODE Benchmark Run Time 295.40 HH
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