Layer 6 Continuous Irregular Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: continuous irregular,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000737
cIR216_L6_DBC_64c3ef1172_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000737
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.15 mV
Rheobase Current Interval (0.14626, 0.14832] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.0375 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 7.7818 mV
AP 1 Steady State Amplitude Change 13.1188 mV
AP 1 Amplitude 81.7081 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 2.7700 ms
AP 1 Rate of Change Peak to Trough -31.5617 mV/ms
AP 1 AHP Depth 5.7179 mV
AP2 Amplitude 73.9263 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 3.0400 ms
AP 2 Rate of Change Peak to Trough -26.7823 mV/ms
AP 2 AHP Depth 7.4919 mV
AP 1-2 Amplitude Change Percent -9.5239 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -15.1431 %
AP 1-2 AHP Depth Percent Change 31.0265 %
Input Resistance 239.8106 MΩ
AP 1 Delay Mean 10.8100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.2300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.2500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -38.4615 %
Steady State Accommodation Mean -30.7692 %
Accommodation Rate to Steady State -0.1297 %/ms
Accommodation at Steady State Mean -81.6419 %
Accommodation Rate Mean at Steady State 125.8531 ms
ISI CV 4.2014
ISI Median 47.3000 ms
ISI Burst Mean Change 27.2727 %
Spike Rate (Strong Stimulation) 62.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.7000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.3400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.6950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2027.0600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4654.39 µm2
Number of Stems 4.0
Number of Bifurcations 52.0
Number of Branches 107.0
Overall Width 341.873 µm
Overall Height 593.223 µm
Overall Depth 246.42 µm
Average Diameter 0.732229 µm
Total Length 6459.07 µm
Total Surface 13581.8 µm2
Total Volume 4000.01 µm3
Max Euclidean Distance 352.594 µm
Max Path Distance 688.71 µm
Max Branch Order 11.0
Average Contraction 0.947351
Total Fragmentation 5939.0
Partition Asymmetry 0.490463
Average Rall's Ratio 0.97881
Average Bifurcation Angle Local 28.8295 °
Average Bifurcation Angle Remote 55.4978 °
Fractal Dimension 1.01024
Complexity Summary
State Equations 3583
Optimal Time-Step 0.00546 ms
Relative Complexity 1298.30 HH
Model Size
Sections 108
Compartments 324
State Equations 3583
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00546 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 1298.30 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.03 %
Max. Stable Time-Step Benchmark Run Time 3545.28 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 20005 Hz
CVODE Steps Per AP 237
CVODE Benchmark Run Time 1043.32 HH
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