Layer 5 Continuous Irregular Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, continuous irregular nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000736
cIR216_L5_NBC_ded84149de_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000736
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.74 mV
Rheobase Current Interval (0.10025, 0.10162] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0288 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 2.5217 mV
AP 1 Steady State Amplitude Change 5.0058 mV
AP 1 Amplitude 88.4545 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 2.4300 ms
AP 1 Rate of Change Peak to Trough -45.3838 mV/ms
AP 1 AHP Depth 21.8280 mV
AP2 Amplitude 85.9328 mV
AP2 Width at Half Height 0.5300 ms
AP 2 Width (Peak to Trough) 2.5000 ms
AP 2 Rate of Change Peak to Trough -43.8090 mV/ms
AP 2 AHP Depth 23.5896 mV
AP 1-2 Amplitude Change Percent -2.8509 %
AP 1-2 Half Width Change Percent -3.6364 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4699 %
AP 1-2 AHP Depth Percent Change 8.0706 %
Input Resistance 337.0483 MΩ
AP 1 Delay Mean 11.5700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 31.4300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 21.2950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1151 %/ms
Accommodation at Steady State Mean -80.7481 %
Accommodation Rate Mean at Steady State 171.3106 ms
ISI CV 3.7249
ISI Median 66.7500 ms
ISI Burst Mean Change 14.4512 %
Spike Rate (Strong Stimulation) 29.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.5600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.7500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.9000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2031.5800 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5102 Hz
Frequency Filter Pass Below 54.5995 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5354.07 µm2
Number of Stems 5.0
Number of Bifurcations 34.0
Number of Branches 72.0
Overall Width 569.045 µm
Overall Height 528.302 µm
Overall Depth 186.45 µm
Average Diameter 0.698947 µm
Total Length 5803.91 µm
Total Surface 11147.8 µm2
Total Volume 3470.46 µm3
Max Euclidean Distance 654.526 µm
Max Path Distance 837.16 µm
Max Branch Order 11.0
Average Contraction 0.957232
Total Fragmentation 2033.0
Partition Asymmetry 0.53421
Average Rall's Ratio 1.3125
Average Bifurcation Angle Local 48.9017 °
Average Bifurcation Angle Remote 67.305 °
Fractal Dimension 1.00723
Complexity Summary
Relative Complexity 923.06 HH
State Equations 3264
Optimal Time-Step 0.00782 ms
Model Size
Sections 73
Compartments 295
State Equations 3264
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19787 Hz
CVODE Steps Per AP 248
CVODE Benchmark Run Time 923.06 HH
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