Layer 5 Continuous Irregular Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000731
cIR216_L5_LBC_c5448109e7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000731
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.54 mV
Rheobase Current Interval (0.10735, 0.10895] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0267 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.7430 mV
AP 1 Steady State Amplitude Change 7.9423 mV
AP 1 Amplitude 86.1971 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 3.3400 ms
AP 1 Rate of Change Peak to Trough -29.7521 mV/ms
AP 1 AHP Depth 13.1748 mV
AP2 Amplitude 82.4541 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 3.4900 ms
AP 2 Rate of Change Peak to Trough -28.0186 mV/ms
AP 2 AHP Depth 15.3308 mV
AP 1-2 Amplitude Change Percent -4.3424 %
AP 1-2 Half Width Change Percent -1.5625 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.8264 %
AP 1-2 AHP Depth Percent Change 16.3646 %
Input Resistance 376.1671 MΩ
AP 1 Delay Mean 10.7400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 27.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.3500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -36.3636 %
Accommodation Rate to Steady State -0.1507 %/ms
Accommodation at Steady State Mean -81.5136 %
Accommodation Rate Mean at Steady State 137.7732 ms
ISI CV 3.9753
ISI Median 56.3950 ms
ISI Burst Mean Change 16.9031 %
Spike Rate (Strong Stimulation) 37.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.1100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.4800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.9500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2036.8800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 70.5798 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6212.91 µm2
Number of Stems 7.0
Number of Bifurcations 13.0
Number of Branches 32.0
Overall Width 431.415 µm
Overall Height 576.45 µm
Overall Depth 132.58 µm
Average Diameter 1.04116 µm
Total Length 3045.75 µm
Total Surface 7793.43 µm2
Total Volume 3133.58 µm3
Max Euclidean Distance 457.409 µm
Max Path Distance 503.64 µm
Max Branch Order 3.0
Average Contraction 0.971747
Total Fragmentation 626.0
Partition Asymmetry 0.384615
Average Rall's Ratio 0.766667
Average Bifurcation Angle Local 44.6998 °
Average Bifurcation Angle Remote 47.2114 °
Fractal Dimension 1.00467
Complexity Summary
State Equations 1724
Optimal Time-Step 0.00775 ms
Relative Complexity 447.35 HH
Model Size
Sections 33
Compartments 155
State Equations 1724
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.38 %
Optimal Time-Step Benchmark Run Time 447.35 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.82 %
Max. Stable Time-Step Benchmark Run Time 866.79 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16673 Hz
CVODE Steps Per AP 180
CVODE Benchmark Run Time 421.39 HH
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