Layer 5 Continuous Irregular Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000730
cIR216_L5_LBC_c3984af99c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000730
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.46 mV
Rheobase Current Interval (0.16479, 0.16663] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -70.00 mV) 0.0402 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.6720 mV
AP 1 Steady State Amplitude Change 8.3670 mV
AP 1 Amplitude 88.2238 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 2.4800 ms
AP 1 Rate of Change Peak to Trough -42.2336 mV/ms
AP 1 AHP Depth 16.5155 mV
AP2 Amplitude 84.5519 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.4700 ms
AP 2 Rate of Change Peak to Trough -41.8687 mV/ms
AP 2 AHP Depth 18.8639 mV
AP 1-2 Amplitude Change Percent -4.1621 %
AP 1-2 Half Width Change Percent -6.5574 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.8640 %
AP 1-2 AHP Depth Percent Change 14.2191 %
Input Resistance 259.3400 MΩ
AP 1 Delay Mean 8.4500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 21.6300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 14.8400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.2097 %/ms
Accommodation at Steady State Mean -91.0221 %
Accommodation Rate Mean at Steady State 94.5009 ms
ISI CV 3.6931
ISI Median 65.0100 ms
ISI Burst Mean Change 25.1897 %
Spike Rate (Strong Stimulation) 34.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.1200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.9950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2025.7100 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5056 Hz
Frequency Filter Pass Below 87.8927 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 16518.1 µm2
Number of Stems 7.0
Number of Bifurcations 30.0
Number of Branches 66.0
Overall Width 572.593 µm
Overall Height 698.702 µm
Overall Depth 326.45 µm
Average Diameter 0.533348 µm
Total Length 7695.89 µm
Total Surface 12429.8 µm2
Total Volume 7851.82 µm3
Max Euclidean Distance 543.108 µm
Max Path Distance 606.191 µm
Max Branch Order 6.0
Average Contraction 0.949562
Total Fragmentation 5084.0
Partition Asymmetry 0.315397
Average Rall's Ratio 0.80125
Average Bifurcation Angle Local 18.1757 °
Average Bifurcation Angle Remote 43.254 °
Fractal Dimension 1.00993
Complexity Summary
State Equations 4254
Optimal Time-Step 0.00788 ms
Relative Complexity 1109.56 HH
Model Size
Sections 67
Compartments 385
State Equations 4254
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00788 ms
Optimal Time-Step Error 0.45 %
Optimal Time-Step Benchmark Run Time 1109.56 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.33 %
Max. Stable Time-Step Benchmark Run Time 2184.93 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18896 Hz
CVODE Steps Per AP 245
CVODE Benchmark Run Time 1226.88 HH
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