Layer 5 Continuous Irregular Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, continuous irregular large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000729
cIR216_L5_LBC_b2c5f59c1a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000729
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.43 mV
Rheobase Current Interval (0.07233, 0.07324] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0188 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 4.8024 mV
AP 1 Steady State Amplitude Change 7.7598 mV
AP 1 Amplitude 89.5284 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 2.7200 ms
AP 1 Rate of Change Peak to Trough -38.4848 mV/ms
AP 1 AHP Depth 15.1503 mV
AP2 Amplitude 84.7260 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 2.7100 ms
AP 2 Rate of Change Peak to Trough -37.7891 mV/ms
AP 2 AHP Depth 17.6825 mV
AP 1-2 Amplitude Change Percent -5.3641 %
AP 1-2 Half Width Change Percent -4.9180 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.8077 %
AP 1-2 AHP Depth Percent Change 16.7142 %
Input Resistance 572.9990 MΩ
AP 1 Delay Mean 9.3100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.9400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 17.1250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.2177 %/ms
Accommodation at Steady State Mean -87.9281 %
Accommodation Rate Mean at Steady State 106.8815 ms
ISI CV 3.7488
ISI Median 64.8000 ms
ISI Burst Mean Change 19.1299 %
Spike Rate (Strong Stimulation) 36.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.5900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.8400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.6200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2030.9000 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5072 Hz
Frequency Filter Pass Below 68.6338 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4247.99 µm2
Number of Stems 5.0
Number of Bifurcations 25.0
Number of Branches 54.0
Overall Width 344.38 µm
Overall Height 517.947 µm
Overall Depth 179.57 µm
Average Diameter 0.692476 µm
Total Length 3060.55 µm
Total Surface 6363.02 µm2
Total Volume 2361.68 µm3
Max Euclidean Distance 380.062 µm
Max Path Distance 652.103 µm
Max Branch Order 9.0
Average Contraction 0.955882
Total Fragmentation 2430.0
Partition Asymmetry 0.624322
Average Rall's Ratio 0.914783
Average Bifurcation Angle Local 19.5001 °
Average Bifurcation Angle Remote 59.6999 °
Fractal Dimension 1.00754
Complexity Summary
Relative Complexity 518.43 HH
State Equations 1746
Optimal Time-Step 0.00540 ms
Model Size
Sections 55
Compartments 157
State Equations 1746
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19609 Hz
CVODE Steps Per AP 286
CVODE Benchmark Run Time 518.43 HH
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