Layer 5 Continuous Irregular Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000727
cIR216_L5_LBC_34458d6725_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000727
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.51 mV
Rheobase Current Interval (0.18402, 0.18677] nA
Threshold Current Interval (0.64453, 0.70312] nA
Bias Current (to -70.00 mV) 0.0485 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 5.2233 mV
AP 1 Steady State Amplitude Change 9.2303 mV
AP 1 Amplitude 83.7810 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 3.2400 ms
AP 1 Rate of Change Peak to Trough -28.8439 mV/ms
AP 1 AHP Depth 9.6734 mV
AP2 Amplitude 78.5577 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 3.4500 ms
AP 2 Rate of Change Peak to Trough -26.3299 mV/ms
AP 2 AHP Depth 12.2805 mV
AP 1-2 Amplitude Change Percent -6.2345 %
AP 1-2 Half Width Change Percent -1.4706 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.7160 %
AP 1-2 AHP Depth Percent Change 26.9515 %
Input Resistance 208.7086 MΩ
AP 1 Delay Mean 11.3600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 28.4900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.7350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -36.3636 %
Accommodation Rate to Steady State -0.1464 %/ms
Accommodation at Steady State Mean -80.8726 %
Accommodation Rate Mean at Steady State 136.7169 ms
ISI CV 4.0581
ISI Median 56.4750 ms
ISI Burst Mean Change 18.7391 %
Spike Rate (Strong Stimulation) 36.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.1800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.4300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.9600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2027.7700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 79.4821 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10882.0 µm2
Number of Stems 10.0
Number of Bifurcations 72.0
Number of Branches 153.0
Overall Width 319.904 µm
Overall Height 479.795 µm
Overall Depth 233.84 µm
Average Diameter 0.68215 µm
Total Length 8285.64 µm
Total Surface 15236.6 µm2
Total Volume 5606.23 µm3
Max Euclidean Distance 566.542 µm
Max Path Distance 610.61 µm
Max Branch Order 10.0
Average Contraction 0.957382
Total Fragmentation 5000.0
Partition Asymmetry 0.509792
Average Rall's Ratio 1.43685
Average Bifurcation Angle Local 21.3954 °
Average Bifurcation Angle Remote 63.0485 °
Fractal Dimension 1.0085
Complexity Summary
State Equations 4771
Optimal Time-Step 0.00777 ms
Relative Complexity 1384.22 HH
Model Size
Sections 156
Compartments 432
State Equations 4771
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 1384.22 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.83 %
Max. Stable Time-Step Benchmark Run Time 2689.37 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17406 Hz
CVODE Steps Per AP 287
CVODE Benchmark Run Time 1434.84 HH
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