Layer 5 Continuous Irregular Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000726
cIR216_L5_DBC_d8e0abdc7c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000726
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.86 mV
Rheobase Current Interval (0.15610, 0.15862] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -70.00 mV) 0.0377 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.6552 mV
AP 1 Steady State Amplitude Change 8.8280 mV
AP 1 Amplitude 81.4069 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 4.2300 ms
AP 1 Rate of Change Peak to Trough -22.3111 mV/ms
AP 1 AHP Depth 12.9689 mV
AP2 Amplitude 77.7516 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 4.3200 ms
AP 2 Rate of Change Peak to Trough -21.5090 mV/ms
AP 2 AHP Depth 15.1673 mV
AP 1-2 Amplitude Change Percent -4.4901 %
AP 1-2 Half Width Change Percent -1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.5948 %
AP 1-2 AHP Depth Percent Change 16.9512 %
Input Resistance 277.0384 MΩ
AP 1 Delay Mean 10.9900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 28.3900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.8250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -36.3636 %
Accommodation Rate to Steady State -0.1354 %/ms
Accommodation at Steady State Mean -82.4463 %
Accommodation Rate Mean at Steady State 128.5876 ms
ISI CV 3.9906
ISI Median 58.4800 ms
ISI Burst Mean Change 16.3793 %
Spike Rate (Strong Stimulation) 36.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.5200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.3200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.3950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2039.9300 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5102 Hz
Frequency Filter Pass Below 69.5964 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10132.8 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 172.995 µm
Overall Height 364.558 µm
Overall Depth 144.89 µm
Average Diameter 1.43865 µm
Total Length 2577.38 µm
Total Surface 10797.3 µm2
Total Volume 6232.46 µm3
Max Euclidean Distance 209.278 µm
Max Path Distance 245.651 µm
Max Branch Order 6.0
Average Contraction 0.977471
Total Fragmentation 903.0
Partition Asymmetry 0.413136
Average Rall's Ratio 1.066
Average Bifurcation Angle Local 23.0712 °
Average Bifurcation Angle Remote 43.5628 °
Fractal Dimension 1.00301
Complexity Summary
State Equations 1438
Optimal Time-Step 0.00771 ms
Relative Complexity 347.73 HH
Model Size
Sections 63
Compartments 129
State Equations 1438
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.38 %
Optimal Time-Step Benchmark Run Time 347.73 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.89 %
Max. Stable Time-Step Benchmark Run Time 670.05 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13672 Hz
CVODE Steps Per AP 291
CVODE Benchmark Run Time 292.24 HH
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