Layer 5 Continuous Irregular Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: continuous irregular,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, continuous irregular double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000722
cIR216_L5_DBC_30f853b5ca_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000722
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.98 mV
Rheobase Current Interval (0.14832, 0.15038] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.0379 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 8.4380 mV
AP 1 Steady State Amplitude Change 13.9088 mV
AP 1 Amplitude 82.6050 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 2.7800 ms
AP 1 Rate of Change Peak to Trough -31.7461 mV/ms
AP 1 AHP Depth 5.6493 mV
AP2 Amplitude 74.1670 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 3.0100 ms
AP 2 Rate of Change Peak to Trough -27.3391 mV/ms
AP 2 AHP Depth 8.1236 mV
AP 1-2 Amplitude Change Percent -10.2149 %
AP 1-2 Half Width Change Percent -1.4925 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.8822 %
AP 1-2 AHP Depth Percent Change 43.7986 %
Input Resistance 231.2220 MΩ
AP 1 Delay Mean 10.5800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.6900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 14.9700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -38.4615 %
Steady State Accommodation Mean -38.4615 %
Accommodation Rate to Steady State -0.1644 %/ms
Accommodation at Steady State Mean -82.0405 %
Accommodation Rate Mean at Steady State 125.0862 ms
ISI CV 4.1738
ISI Median 47.0600 ms
ISI Burst Mean Change 28.3753 %
Spike Rate (Strong Stimulation) 63.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.6850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2025.9000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4654.39 µm2
Number of Stems 4.0
Number of Bifurcations 52.0
Number of Branches 107.0
Overall Width 445.883 µm
Overall Height 614.769 µm
Overall Depth 220.3 µm
Average Diameter 0.732229 µm
Total Length 6762.42 µm
Total Surface 14270.3 µm2
Total Volume 4185.48 µm3
Max Euclidean Distance 380.227 µm
Max Path Distance 780.64 µm
Max Branch Order 11.0
Average Contraction 0.948951
Total Fragmentation 5939.0
Partition Asymmetry 0.490463
Average Rall's Ratio 0.97881
Average Bifurcation Angle Local 26.1484 °
Average Bifurcation Angle Remote 55.1081 °
Fractal Dimension 1.00979
Complexity Summary
Relative Complexity 1047.89 HH
State Equations 3605
Optimal Time-Step 0.00539 ms
Model Size
Sections 108
Compartments 326
State Equations 3605
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19848 Hz
CVODE Steps Per AP 253
CVODE Benchmark Run Time 1047.89 HH
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