Layer 4 Continuous Irregular Nest Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous irregular,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000720
cIR216_L4_NBC_c28326d13b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000720
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.62 mV
Rheobase Current Interval (0.07141, 0.07278] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0201 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 2.1093 mV
AP 1 Steady State Amplitude Change 5.0624 mV
AP 1 Amplitude 82.9819 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 3.8200 ms
AP 1 Rate of Change Peak to Trough -26.8775 mV/ms
AP 1 AHP Depth 19.6903 mV
AP2 Amplitude 80.8726 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 3.8900 ms
AP 2 Rate of Change Peak to Trough -26.2048 mV/ms
AP 2 AHP Depth 21.0640 mV
AP 1-2 Amplitude Change Percent -2.5418 %
AP 1-2 Half Width Change Percent -1.5152 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.5031 %
AP 1-2 AHP Depth Percent Change 6.9763 %
Input Resistance 596.0103 MΩ
AP 1 Delay Mean 12.6300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 34.5500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 23.4450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -37.5000 %
Steady State Accommodation Mean -37.5000 %
Accommodation Rate to Steady State -0.1496 %/ms
Accommodation at Steady State Mean -84.7021 %
Accommodation Rate Mean at Steady State 137.7932 ms
ISI CV 3.5892
ISI Median 81.3800 ms
ISI Burst Mean Change 13.9142 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.0700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.7500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.5800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.9100 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5176 Hz
Frequency Filter Pass Below 55.5479 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4504.54 µm2
Number of Stems 10.0
Number of Bifurcations 18.0
Number of Branches 45.0
Overall Width 169.126 µm
Overall Height 335.666 µm
Overall Depth 111.68 µm
Average Diameter 0.783132 µm
Total Length 2306.5 µm
Total Surface 5198.59 µm2
Total Volume 2121.73 µm3
Max Euclidean Distance 237.231 µm
Max Path Distance 262.509 µm
Max Branch Order 5.0
Average Contraction 0.958672
Total Fragmentation 918.0
Partition Asymmetry 0.468519
Average Rall's Ratio 1.0825
Average Bifurcation Angle Local 35.0112 °
Average Bifurcation Angle Remote 67.9299 °
Fractal Dimension 1.00593
Complexity Summary
State Equations 1361
Optimal Time-Step 0.00781 ms
Relative Complexity 336.57 HH
Model Size
Sections 46
Compartments 122
State Equations 1361
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00781 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 336.57 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.93 %
Max. Stable Time-Step Benchmark Run Time 657.30 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15489 Hz
CVODE Steps Per AP 216
CVODE Benchmark Run Time 305.14 HH
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