Layer 4 Continuous Irregular Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous irregular,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000718
cIR216_L4_NBC_7eb58fa61e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000718
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.29 mV
Rheobase Current Interval (0.10712, 0.10849] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0270 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 4.5604 mV
AP 1 Steady State Amplitude Change 10.2324 mV
AP 1 Amplitude 86.4615 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 2.6500 ms
AP 1 Rate of Change Peak to Trough -36.5347 mV/ms
AP 1 AHP Depth 10.3553 mV
AP2 Amplitude 81.9011 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 2.7400 ms
AP 2 Rate of Change Peak to Trough -34.2769 mV/ms
AP 2 AHP Depth 12.0175 mV
AP 1-2 Amplitude Change Percent -5.2745 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.1798 %
AP 1-2 AHP Depth Percent Change 16.0513 %
Input Resistance 345.6100 MΩ
AP 1 Delay Mean 10.9200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.8700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 16.5450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -35.7143 %
Steady State Accommodation Mean -35.7143 %
Accommodation Rate to Steady State -0.1202 %/ms
Accommodation at Steady State Mean -75.3057 %
Accommodation Rate Mean at Steady State 158.5332 ms
ISI CV 4.4587
ISI Median 44.8300 ms
ISI Burst Mean Change 21.3378 %
Spike Rate (Strong Stimulation) 49.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.5500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.7300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.5950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2027.8700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 126.6624 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2893.63 µm2
Number of Stems 4.0
Number of Bifurcations 23.0
Number of Branches 49.0
Overall Width 353.55 µm
Overall Height 520.209 µm
Overall Depth 345.1 µm
Average Diameter 0.692906 µm
Total Length 4978.09 µm
Total Surface 8957.26 µm2
Total Volume 2182.37 µm3
Max Euclidean Distance 372.01 µm
Max Path Distance 433.549 µm
Max Branch Order 6.0
Average Contraction 0.951827
Total Fragmentation 1139.0
Partition Asymmetry 0.43362
Average Rall's Ratio 1.26235
Average Bifurcation Angle Local 34.0649 °
Average Bifurcation Angle Remote 58.2409 °
Fractal Dimension 1.00815
Complexity Summary
State Equations 2747
Optimal Time-Step 0.00770 ms
Relative Complexity 645.41 HH
Model Size
Sections 50
Compartments 248
State Equations 2747
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00770 ms
Optimal Time-Step Error 0.47 %
Optimal Time-Step Benchmark Run Time 645.41 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.19 %
Max. Stable Time-Step Benchmark Run Time 1241.85 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17546 Hz
CVODE Steps Per AP 206
CVODE Benchmark Run Time 640.63 HH
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