Layer 4 Continuous Irregular Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous irregular,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000716
cIR216_L4_DBC_e15869b926_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000716
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.77 mV
Rheobase Current Interval (0.12337, 0.12497] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0295 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.9036 mV
AP 1 Steady State Amplitude Change 9.0085 mV
AP 1 Amplitude 88.5604 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 3.0500 ms
AP 1 Rate of Change Peak to Trough -32.9703 mV/ms
AP 1 AHP Depth 11.9991 mV
AP2 Amplitude 84.6568 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 3.1600 ms
AP 2 Rate of Change Peak to Trough -31.2734 mV/ms
AP 2 AHP Depth 14.1671 mV
AP 1-2 Amplitude Change Percent -4.4078 %
AP 1-2 Half Width Change Percent -4.8387 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.1469 %
AP 1-2 AHP Depth Percent Change 18.0676 %
Input Resistance 347.3238 MΩ
AP 1 Delay Mean 9.6200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.5300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 16.3600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -36.3636 %
Accommodation Rate to Steady State -0.1455 %/ms
Accommodation at Steady State Mean -84.8852 %
Accommodation Rate Mean at Steady State 113.9397 ms
ISI CV 3.9875
ISI Median 54.9300 ms
ISI Burst Mean Change 19.4500 %
Spike Rate (Strong Stimulation) 41.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.7400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.6800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.3550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2030.9600 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5056 Hz
Frequency Filter Pass Below 72.0632 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7858.86 µm2
Number of Stems 4.0
Number of Bifurcations 41.0
Number of Branches 85.0
Overall Width 222.29 µm
Overall Height 546.518 µm
Overall Depth 151.79 µm
Average Diameter 0.89558 µm
Total Length 3130.51 µm
Total Surface 8142.92 µm2
Total Volume 4055.06 µm3
Max Euclidean Distance 422.811 µm
Max Path Distance 444.43 µm
Max Branch Order 9.0
Average Contraction 0.953626
Total Fragmentation 1032.0
Partition Asymmetry 0.495599
Average Rall's Ratio 0.776667
Average Bifurcation Angle Local 58.7683 °
Average Bifurcation Angle Remote 66.2658 °
Fractal Dimension 1.00564
Complexity Summary
State Equations 1933
Optimal Time-Step 0.00768 ms
Relative Complexity 459.30 HH
Model Size
Sections 86
Compartments 174
State Equations 1933
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.40 %
Optimal Time-Step Benchmark Run Time 459.30 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.00 %
Max. Stable Time-Step Benchmark Run Time 881.24 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15912 Hz
CVODE Steps Per AP 264
CVODE Benchmark Run Time 430.23 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS