Layer 4 Continuous Irregular Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous irregular,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000714
cIR216_L4_DBC_90f039ca46_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000714
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.72 mV
Rheobase Current Interval (0.12909, 0.13046] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0321 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 2.7736 mV
AP 1 Steady State Amplitude Change 6.7859 mV
AP 1 Amplitude 90.7429 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 2.2900 ms
AP 1 Rate of Change Peak to Trough -47.7675 mV/ms
AP 1 AHP Depth 18.6446 mV
AP2 Amplitude 87.9693 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 2.2700 ms
AP 2 Rate of Change Peak to Trough -47.8326 mV/ms
AP 2 AHP Depth 20.6108 mV
AP 1-2 Amplitude Change Percent -3.0566 %
AP 1-2 Half Width Change Percent -3.4483 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1364 %
AP 1-2 AHP Depth Percent Change 10.5454 %
Input Resistance 343.8348 MΩ
AP 1 Delay Mean 8.4300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 20.9800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 14.4400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -30.0000 %
Accommodation Rate to Steady State -0.1667 %/ms
Accommodation at Steady State Mean -90.6677 %
Accommodation Rate Mean at Steady State 99.3481 ms
ISI CV 3.7284
ISI Median 64.5650 ms
ISI Burst Mean Change 30.1195 %
Spike Rate (Strong Stimulation) 33.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.0900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.6050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2028.5200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 122.7410 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11222.4 µm2
Number of Stems 4.0
Number of Bifurcations 30.0
Number of Branches 63.0
Overall Width 193.258 µm
Overall Height 599.957 µm
Overall Depth 76.71 µm
Average Diameter 0.914275 µm
Total Length 2842.53 µm
Total Surface 8780.5 µm2
Total Volume 6211.91 µm3
Max Euclidean Distance 420.773 µm
Max Path Distance 482.245 µm
Max Branch Order 6.0
Average Contraction 0.910943
Total Fragmentation 3461.0
Partition Asymmetry 0.406111
Average Rall's Ratio 0.4202
Average Bifurcation Angle Local 39.0876 °
Average Bifurcation Angle Remote 64.6842 °
Fractal Dimension 1.01996
Complexity Summary
State Equations 1691
Optimal Time-Step 0.00775 ms
Relative Complexity 406.49 HH
Model Size
Sections 64
Compartments 152
State Equations 1691
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 406.49 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.03 %
Max. Stable Time-Step Benchmark Run Time 787.29 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17790 Hz
CVODE Steps Per AP 213
CVODE Benchmark Run Time 412.51 HH
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