Layer 2/3 Continuous Irregular Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous irregular,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000707
cIR216_L23_NBC_1f21a64cc1_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000707
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.01 mV
Rheobase Current Interval (0.09888, 0.10071] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -70.00 mV) 0.0241 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 4.8804 mV
AP 1 Steady State Amplitude Change 9.7811 mV
AP 1 Amplitude 77.7423 mV
AP 1 Width at Half Height 0.8400 ms
AP 1 Width (Peak To Trough) 4.7400 ms
AP 1 Rate of Change Peak to Trough -18.3750 mV/ms
AP 1 AHP Depth 9.3554 mV
AP2 Amplitude 72.8619 mV
AP2 Width at Half Height 0.8500 ms
AP 2 Width (Peak to Trough) 5.0300 ms
AP 2 Rate of Change Peak to Trough -16.8600 mV/ms
AP 2 AHP Depth 11.9439 mV
AP 1-2 Amplitude Change Percent -6.2777 %
AP 1-2 Half Width Change Percent 1.1905 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.2451 %
AP 1-2 AHP Depth Percent Change 27.6687 %
Input Resistance 434.7235 MΩ
AP 1 Delay Mean 11.4300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 29.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.2850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -36.3636 %
Steady State Accommodation Mean -36.3636 %
Accommodation Rate to Steady State -0.1356 %/ms
Accommodation at Steady State Mean -81.5834 %
Accommodation Rate Mean at Steady State 129.7511 ms
ISI CV 4.0276
ISI Median 57.9700 ms
ISI Burst Mean Change 16.4422 %
Spike Rate (Strong Stimulation) 37.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.8000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.7000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.4950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2022.6100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 131.5433 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3648.35 µm2
Number of Stems 9.0
Number of Bifurcations 26.0
Number of Branches 60.0
Overall Width 249.384 µm
Overall Height 275.621 µm
Overall Depth 159.27 µm
Average Diameter 0.82778 µm
Total Length 3257.94 µm
Total Surface 7027.66 µm2
Total Volume 2336.06 µm3
Max Euclidean Distance 212.092 µm
Max Path Distance 236.381 µm
Max Branch Order 7.0
Average Contraction 0.968281
Total Fragmentation 886.0
Partition Asymmetry 0.367333
Average Rall's Ratio 1.36786
Average Bifurcation Angle Local 38.0665 °
Average Bifurcation Angle Remote 51.3246 °
Fractal Dimension 1.00503
Complexity Summary
State Equations 1878
Optimal Time-Step 0.00920 ms
Relative Complexity 399.42 HH
Model Size
Sections 61
Compartments 169
State Equations 1878
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00920 ms
Optimal Time-Step Error 1.83 %
Optimal Time-Step Benchmark Run Time 399.42 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 3.09 %
Max. Stable Time-Step Benchmark Run Time 918.71 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13154 Hz
CVODE Steps Per AP 331
CVODE Benchmark Run Time 397.95 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS