Layer 1 Continuous Irregular Horizontal Axon Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous irregular,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000706
cIR216_L1_HAC_edfad4a560_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000706
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.12 mV
Rheobase Current Interval (0.07324, 0.07439] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0188 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 5.5436 mV
AP 1 Steady State Amplitude Change 10.5375 mV
AP 1 Amplitude 86.2877 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.4100 ms
AP 1 Rate of Change Peak to Trough -28.6445 mV/ms
AP 1 AHP Depth 11.3899 mV
AP2 Amplitude 80.7441 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 3.5000 ms
AP 2 Rate of Change Peak to Trough -27.1752 mV/ms
AP 2 AHP Depth 14.3691 mV
AP 1-2 Amplitude Change Percent -6.4246 %
AP 1-2 Half Width Change Percent -3.0769 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.1293 %
AP 1-2 AHP Depth Percent Change 26.1564 %
Input Resistance 606.5683 MΩ
AP 1 Delay Mean 9.8900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.8200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 17.6650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -44.4444 %
Accommodation Rate to Steady State -0.1931 %/ms
Accommodation at Steady State Mean -88.3711 %
Accommodation Rate Mean at Steady State 90.7783 ms
ISI CV 3.8800
ISI Median 67.0800 ms
ISI Burst Mean Change 21.7828 %
Spike Rate (Strong Stimulation) 35.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.1400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.0800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2034.9600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 108.1333 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5477.78 µm2
Number of Stems 8.0
Number of Bifurcations 17.0
Number of Branches 41.0
Overall Width 265.323 µm
Overall Height 283.332 µm
Overall Depth 182.63 µm
Average Diameter 0.703795 µm
Total Length 2616.91 µm
Total Surface 4843.8 µm2
Total Volume 2138.61 µm3
Max Euclidean Distance 217.07 µm
Max Path Distance 302.898 µm
Max Branch Order 6.0
Average Contraction 0.933993
Total Fragmentation 1515.0
Partition Asymmetry 0.613445
Average Rall's Ratio 1.47292
Average Bifurcation Angle Local 34.6844 °
Average Bifurcation Angle Remote 73.6489 °
Fractal Dimension 1.01048
Complexity Summary
State Equations 1449
Optimal Time-Step 0.00536 ms
Relative Complexity 548.67 HH
Model Size
Sections 42
Compartments 130
State Equations 1449
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00536 ms
Optimal Time-Step Error 0.19 %
Optimal Time-Step Benchmark Run Time 548.67 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.91 %
Max. Stable Time-Step Benchmark Run Time 1469.29 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16387 Hz
CVODE Steps Per AP 301
CVODE Benchmark Run Time 374.98 HH
Website & Images Copyright NeuroML © 2021 For questions: Contact us Links: Search Test |  ModelDB WS