Layer 1 Continuous Irregular Horizontal Axon Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous irregular,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000705
cIR216_L1_HAC_cc210b8244_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000705
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.18 mV
Rheobase Current Interval (0.06638, 0.06752] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0174 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 4.8547 mV
AP 1 Steady State Amplitude Change 8.5132 mV
AP 1 Amplitude 84.9223 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 3.5400 ms
AP 1 Rate of Change Peak to Trough -28.0596 mV/ms
AP 1 AHP Depth 14.4089 mV
AP2 Amplitude 80.0675 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 3.6900 ms
AP 2 Rate of Change Peak to Trough -26.4261 mV/ms
AP 2 AHP Depth 17.4448 mV
AP 1-2 Amplitude Change Percent -5.7166 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.8216 %
AP 1-2 AHP Depth Percent Change 21.0701 %
Input Resistance 715.0485 MΩ
AP 1 Delay Mean 10.0900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.9800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.8400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -37.5000 %
Steady State Accommodation Mean -37.5000 %
Accommodation Rate to Steady State -0.1766 %/ms
Accommodation at Steady State Mean -89.6271 %
Accommodation Rate Mean at Steady State 90.8823 ms
ISI CV 3.7585
ISI Median 79.7900 ms
ISI Burst Mean Change 23.0906 %
Spike Rate (Strong Stimulation) 26.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.3900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.7500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.0450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2034.1600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 74.4310 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5680.93 µm2
Number of Stems 5.0
Number of Bifurcations 21.0
Number of Branches 46.0
Overall Width 148.035 µm
Overall Height 173.446 µm
Overall Depth 77.22 µm
Average Diameter 0.799549 µm
Total Length 1920.61 µm
Total Surface 4229.99 µm2
Total Volume 2145.11 µm3
Max Euclidean Distance 155.394 µm
Max Path Distance 193.413 µm
Max Branch Order 6.0
Average Contraction 0.941089
Total Fragmentation 1124.0
Partition Asymmetry 0.464701
Average Rall's Ratio 1.53125
Average Bifurcation Angle Local 43.9417 °
Average Bifurcation Angle Remote 83.6087 °
Fractal Dimension 1.01121
Complexity Summary
State Equations 1130
Optimal Time-Step 0.00770 ms
Relative Complexity 284.84 HH
Model Size
Sections 47
Compartments 101
State Equations 1130
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00770 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 284.84 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.80 %
Max. Stable Time-Step Benchmark Run Time 548.41 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14629 Hz
CVODE Steps Per AP 228
CVODE Benchmark Run Time 243.95 HH
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