Layer 1 Continuous Irregular Horizontal Axon Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous irregular,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon, biophysical, continuous irregular horizontal axon cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000704
cIR216_L1_HAC_a67a175a7c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000704
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.17 mV
Rheobase Current Interval (0.07439, 0.07553] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0191 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 5.4564 mV
AP 1 Steady State Amplitude Change 11.0181 mV
AP 1 Amplitude 82.8785 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 3.7900 ms
AP 1 Rate of Change Peak to Trough -24.7755 mV/ms
AP 1 AHP Depth 11.0207 mV
AP2 Amplitude 77.4222 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 3.9400 ms
AP 2 Rate of Change Peak to Trough -23.1800 mV/ms
AP 2 AHP Depth 13.9072 mV
AP 1-2 Amplitude Change Percent -6.5836 %
AP 1-2 Half Width Change Percent -1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.4398 %
AP 1-2 AHP Depth Percent Change 26.1915 %
Input Resistance 611.3267 MΩ
AP 1 Delay Mean 10.3400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.7200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.1950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1563 %/ms
Accommodation at Steady State Mean -86.8582 %
Accommodation Rate Mean at Steady State 99.6130 ms
ISI CV 3.9027
ISI Median 65.6550 ms
ISI Burst Mean Change 22.1612 %
Spike Rate (Strong Stimulation) 33.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.3100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.1900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.4850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2027.8300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 79.3577 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4786.14 µm2
Number of Stems 7.0
Number of Bifurcations 43.0
Number of Branches 92.0
Overall Width 167.776 µm
Overall Height 283.332 µm
Overall Depth 109.96 µm
Average Diameter 0.505361 µm
Total Length 3228.4 µm
Total Surface 5063.25 µm2
Total Volume 1971.33 µm3
Max Euclidean Distance 212.939 µm
Max Path Distance 267.511 µm
Max Branch Order 5.0
Average Contraction 0.90696
Total Fragmentation 3114.0
Partition Asymmetry 0.352079
Average Rall's Ratio 1.2065
Average Bifurcation Angle Local 38.3569 °
Average Bifurcation Angle Remote 75.2081 °
Fractal Dimension 1.01955
Complexity Summary
Relative Complexity 521.15 HH
State Equations 1922
Optimal Time-Step 0.00537 ms
Model Size
Sections 93
Compartments 173
State Equations 1922
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17803 Hz
CVODE Steps Per AP 302
CVODE Benchmark Run Time 521.15 HH
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