Layer 1 Continuous Irregular Horizontal Axon Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous irregular,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000703
cIR216_L1_HAC_84f0f8f321_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000703
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.27 mV
Rheobase Current Interval (0.06866, 0.06981] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0176 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 4.1780 mV
AP 1 Steady State Amplitude Change 6.1379 mV
AP 1 Amplitude 90.2896 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 3.0600 ms
AP 1 Rate of Change Peak to Trough -35.3476 mV/ms
AP 1 AHP Depth 17.8739 mV
AP2 Amplitude 86.1116 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 3.1000 ms
AP 2 Rate of Change Peak to Trough -34.4547 mV/ms
AP 2 AHP Depth 20.6981 mV
AP 1-2 Amplitude Change Percent -4.6273 %
AP 1-2 Half Width Change Percent -3.3333 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.5258 %
AP 1-2 AHP Depth Percent Change 15.8006 %
Input Resistance 726.8925 MΩ
AP 1 Delay Mean 9.4100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.9100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 17.4100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -28.5714 %
Steady State Accommodation Mean -28.5714 %
Accommodation Rate to Steady State -0.1237 %/ms
Accommodation at Steady State Mean -92.3856 %
Accommodation Rate Mean at Steady State 84.7473 ms
ISI CV 3.5784
ISI Median 85.4400 ms
ISI Burst Mean Change 24.6452 %
Spike Rate (Strong Stimulation) 27.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.7600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.1900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2057.0100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 116.9099 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6980.06 µm2
Number of Stems 8.0
Number of Bifurcations 19.0
Number of Branches 45.0
Overall Width 123.721 µm
Overall Height 191.535 µm
Overall Depth 115.53 µm
Average Diameter 0.888794 µm
Total Length 1843.81 µm
Total Surface 3961.37 µm2
Total Volume 2546.93 µm3
Max Euclidean Distance 163.635 µm
Max Path Distance 203.677 µm
Max Branch Order 4.0
Average Contraction 0.950691
Total Fragmentation 877.0
Partition Asymmetry 0.377694
Average Rall's Ratio 0.612692
Average Bifurcation Angle Local 38.9694 °
Average Bifurcation Angle Remote 64.884 °
Fractal Dimension 1.00688
Complexity Summary
State Equations 1075
Optimal Time-Step 0.00544 ms
Relative Complexity 371.28 HH
Model Size
Sections 46
Compartments 96
State Equations 1075
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00544 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 371.28 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.05 %
Max. Stable Time-Step Benchmark Run Time 1008.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14789 Hz
CVODE Steps Per AP 300
CVODE Benchmark Run Time 236.14 HH
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