Layer 1 Continuous Irregular Horizontal Axon Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous irregular,Layer 1,Rat, somatosensory cortex, neocortex, horizontal axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000702
cIR216_L1_HAC_5c847ea2ef_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000702
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.96 mV
Rheobase Current Interval (0.04875, 0.04944] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0131 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 3.2525 mV
AP 1 Steady State Amplitude Change 5.2803 mV
AP 1 Amplitude 91.0043 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 2.8100 ms
AP 1 Rate of Change Peak to Trough -39.8626 mV/ms
AP 1 AHP Depth 21.0097 mV
AP2 Amplitude 87.7518 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.8800 ms
AP 2 Rate of Change Peak to Trough -38.4951 mV/ms
AP 2 AHP Depth 23.1140 mV
AP 1-2 Amplitude Change Percent -3.5740 %
AP 1-2 Half Width Change Percent -5.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4307 %
AP 1-2 AHP Depth Percent Change 10.0158 %
Input Resistance 1058.6792 MΩ
AP 1 Delay Mean 9.6100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.4800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.4250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -42.8571 %
Steady State Accommodation Mean -42.8571 %
Accommodation Rate to Steady State -0.1553 %/ms
Accommodation at Steady State Mean -93.0468 %
Accommodation Rate Mean at Steady State 97.6817 ms
ISI CV 3.2723
ISI Median 101.7800 ms
ISI Burst Mean Change 30.2905 %
Spike Rate (Strong Stimulation) 21.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.0900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.2600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.9350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2059.1800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5045.44 µm2
Number of Stems 6.0
Number of Bifurcations 14.0
Number of Branches 33.0
Overall Width 175.747 µm
Overall Height 203.825 µm
Overall Depth 90.55 µm
Average Diameter 0.697348 µm
Total Length 1561.11 µm
Total Surface 2903.29 µm2
Total Volume 1789.54 µm3
Max Euclidean Distance 185.302 µm
Max Path Distance 202.17 µm
Max Branch Order 6.0
Average Contraction 0.952806
Total Fragmentation 856.0
Partition Asymmetry 0.37381
Average Rall's Ratio 1.42056
Average Bifurcation Angle Local 32.8693 °
Average Bifurcation Angle Remote 61.1351 °
Fractal Dimension 1.00778
Complexity Summary
State Equations 921
Optimal Time-Step 0.00775 ms
Relative Complexity 225.10 HH
Model Size
Sections 34
Compartments 82
State Equations 921
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 225.10 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.52 %
Max. Stable Time-Step Benchmark Run Time 435.75 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14580 Hz
CVODE Steps Per AP 283
CVODE Benchmark Run Time 199.55 HH
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