Layer 5 Continuous Accommodating Untufted Pyramidal Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000701
cADpyr232_L5_UTPC_da1143b075_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000701
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.41 mV
Rheobase Current Interval (0.08789, 0.09064] nA
Threshold Current Interval (0.64453, 0.70312] nA
Bias Current (to -80.00 mV) -0.0481 nA
Testing Temperature 34.0 °C
Stability Interval [-4.6875, 15.0] nA
AP 1-2 Amplitude Drop 1.0958 mV
AP 1 Steady State Amplitude Change 1.2704 mV
AP 1 Amplitude 80.8044 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 2.7600 ms
AP 1 Rate of Change Peak to Trough -32.3293 mV/ms
AP 1 AHP Depth 8.4246 mV
AP2 Amplitude 79.7085 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 28.3900 ms
AP 2 Rate of Change Peak to Trough -3.1755 mV/ms
AP 2 AHP Depth 10.4425 mV
AP 1-2 Amplitude Change Percent -1.3561 %
AP 1-2 Half Width Change Percent -1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change -90.1778 %
AP 1-2 AHP Depth Percent Change 23.9530 %
Input Resistance 155.0670 MΩ
AP 1 Delay Mean 49.6100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 113.6200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 110.7400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1230 %/ms
Accommodation at Steady State Mean -59.9001 %
Accommodation Rate Mean at Steady State 7.2393 ms
ISI CV 5.6776
ISI Median 157.6200 ms
ISI Burst Mean Change 146.0084 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.6400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.0100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.5900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2076.9000 ms
Frequency Filter Type High-Pass
Frequency Filter Pass Above 36.4613 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5818.09 µm2
Number of Stems 8.0
Number of Bifurcations 59.0
Number of Branches 125.0
Overall Width 257.436 µm
Overall Height 722.115 µm
Overall Depth 258.73 µm
Average Diameter 0.536073 µm
Total Length 9190.68 µm
Total Surface 15044.0 µm2
Total Volume 3508.65 µm3
Max Euclidean Distance 745.509 µm
Max Path Distance 763.409 µm
Max Branch Order 18.0
Average Contraction 0.947981
Total Fragmentation 6503.0
Partition Asymmetry 0.588717
Average Rall's Ratio 2.47967
Average Bifurcation Angle Local 55.5508 °
Average Bifurcation Angle Remote 56.0634 °
Fractal Dimension 1.01214
Complexity Summary
State Equations 1935
Optimal Time-Step 0.00807 ms
Relative Complexity 382.67 HH
Model Size
Sections 125
Compartments 463
State Equations 1935
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00807 ms
Optimal Time-Step Error 0.43 %
Optimal Time-Step Benchmark Run Time 382.67 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 771.81 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18288 Hz
CVODE Steps Per AP 114
CVODE Benchmark Run Time 394.52 HH
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