Layer 5 Continuous Accommodating Untufted Pyramidal Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Untufted, pyramidal, rat, neocortex, somatosensory cortex, biophysical, continuous accommodating untufted pyramidal cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000700
cADpyr232_L5_UTPC_d736225429_0_0.cell.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH001436
Ca_HVA.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000700
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.55 mV
Rheobase Current Interval (0.07805, 0.08057] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0413 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 1.0577 mV
AP 1 Steady State Amplitude Change 1.9634 mV
AP 1 Amplitude 80.5259 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 16.9900 ms
AP 1 Rate of Change Peak to Trough -5.3116 mV/ms
AP 1 AHP Depth 9.7183 mV
AP2 Amplitude 79.4682 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 25.7100 ms
AP 2 Rate of Change Peak to Trough -3.5559 mV/ms
AP 2 AHP Depth 11.9553 mV
AP 1-2 Amplitude Change Percent -1.3135 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -33.0532 %
AP 1-2 AHP Depth Percent Change 23.0181 %
Input Resistance 177.6804 MΩ
AP 1 Delay Mean 48.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 120.8200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 119.1600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -56.7250 %
Accommodation Rate Mean at Steady State 42.8883 ms
ISI CV 5.9839
ISI Median 165.6850 ms
ISI Burst Mean Change 127.9934 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.2000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.8000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 36.3950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2069.9500 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.0067 Hz
Frequency Filter Pass Below 137.4738 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5136.95 µm2
Number of Stems 7.0
Number of Bifurcations 45.0
Number of Branches 96.0
Overall Width 253.677 µm
Overall Height 708.904 µm
Overall Depth 224.09 µm
Average Diameter 0.53685 µm
Total Length 8063.4 µm
Total Surface 13442.6 µm2
Total Volume 3112.25 µm3
Max Euclidean Distance 676.523 µm
Max Path Distance 749.156 µm
Max Branch Order 16.0
Average Contraction 0.939105
Total Fragmentation 6339.0
Partition Asymmetry 0.602861
Average Rall's Ratio 2.69935
Average Bifurcation Angle Local 59.6113 °
Average Bifurcation Angle Remote 59.8082 °
Fractal Dimension 1.01392
Complexity Summary
Relative Complexity 378.81 HH
State Equations 1733
Optimal Time-Step 0.00799 ms
Model Size
Sections 98
Compartments 408
State Equations 1733
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18806 Hz
CVODE Steps Per AP 103
CVODE Benchmark Run Time 378.81 HH
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