Layer 5 Continuous Accommodating Untufted Pyramidal Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000699
cADpyr232_L5_UTPC_79412a7e72_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000699
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.22 mV
Rheobase Current Interval (0.08560, 0.08812] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0465 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 0.9056 mV
AP 1 Steady State Amplitude Change -0.8026 mV
AP 1 Amplitude 81.2340 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 3.6900 ms
AP 1 Rate of Change Peak to Trough -24.5745 mV/ms
AP 1 AHP Depth 9.4460 mV
AP2 Amplitude 80.3284 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 21.6000 ms
AP 2 Rate of Change Peak to Trough -4.2117 mV/ms
AP 2 AHP Depth 10.6452 mV
AP 1-2 Amplitude Change Percent -1.1148 %
AP 1-2 Half Width Change Percent 1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change -82.8614 %
AP 1-2 AHP Depth Percent Change 12.6952 %
Input Resistance 165.6548 MΩ
AP 1 Delay Mean 45.1300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 114.0400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 116.6500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1197 %/ms
Accommodation at Steady State Mean -0.6286 %
Accommodation Rate Mean at Steady State 30.7885 ms
ISI CV 5.9179
ISI Median 161.7000 ms
ISI Burst Mean Change 138.5575 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 13.4700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.5800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.9750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2066.2600 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 64.3305 Hz
Frequency Filter Pass Below 69.9985 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6782.39 µm2
Number of Stems 8.0
Number of Bifurcations 63.0
Number of Branches 133.0
Overall Width 281.545 µm
Overall Height 835.134 µm
Overall Depth 253.23 µm
Average Diameter 0.538189 µm
Total Length 9415.37 µm
Total Surface 14965.1 µm2
Total Volume 3812.75 µm3
Max Euclidean Distance 868.766 µm
Max Path Distance 952.177 µm
Max Branch Order 20.0
Average Contraction 0.934315
Total Fragmentation 6863.0
Partition Asymmetry 0.548397
Average Rall's Ratio 2.06538
Average Bifurcation Angle Local 64.5393 °
Average Bifurcation Angle Remote 65.3962 °
Fractal Dimension 1.01296
Complexity Summary
State Equations 2029
Optimal Time-Step 0.01244 ms
Relative Complexity 260.65 HH
Model Size
Sections 134
Compartments 482
State Equations 2029
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.01244 ms
Optimal Time-Step Error 0.37 %
Optimal Time-Step Benchmark Run Time 260.65 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.31 %
Max. Stable Time-Step Benchmark Run Time 810.47 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18406 Hz
CVODE Steps Per AP 141
CVODE Benchmark Run Time 422.59 HH
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