Layer 5 Continuous Accommodating Untufted Pyramidal Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000698
cADpyr232_L5_UTPC_5e3840b51e_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000698
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.59 mV
Rheobase Current Interval (0.08308, 0.08560] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0446 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop -2.1041 mV
AP 1 Steady State Amplitude Change -3.5434 mV
AP 1 Amplitude 78.7109 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 16.3200 ms
AP 1 Rate of Change Peak to Trough -5.6117 mV/ms
AP 1 AHP Depth 12.8726 mV
AP2 Amplitude 80.8150 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 20.9400 ms
AP 2 Rate of Change Peak to Trough -4.5328 mV/ms
AP 2 AHP Depth 14.1018 mV
AP 1-2 Amplitude Change Percent 2.6732 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -19.2264 %
AP 1-2 AHP Depth Percent Change 9.5487 %
Input Resistance 164.1025 MΩ
AP 1 Delay Mean 47.2000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 129.1200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 123.4850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -51.3366 %
Accommodation Rate Mean at Steady State 0.0141 ms
ISI CV 6.6901
ISI Median 166.8050 ms
ISI Burst Mean Change 101.4771 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.4500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 41.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 43.8500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2053.2200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5136.95 µm2
Number of Stems 7.0
Number of Bifurcations 45.0
Number of Branches 96.0
Overall Width 334.073 µm
Overall Height 729.545 µm
Overall Depth 269.92 µm
Average Diameter 0.537007 µm
Total Length 8917.84 µm
Total Surface 14710.4 µm2
Total Volume 3272.56 µm3
Max Euclidean Distance 665.165 µm
Max Path Distance 736.322 µm
Max Branch Order 16.0
Average Contraction 0.939237
Total Fragmentation 6339.0
Partition Asymmetry 0.602861
Average Rall's Ratio 2.69935
Average Bifurcation Angle Local 59.7793 °
Average Bifurcation Angle Remote 60.2135 °
Fractal Dimension 1.01351
Complexity Summary
State Equations 1925
Optimal Time-Step 0.00786 ms
Relative Complexity 407.29 HH
Model Size
Sections 98
Compartments 452
State Equations 1925
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00786 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 407.29 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.46 %
Max. Stable Time-Step Benchmark Run Time 800.14 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18212 Hz
CVODE Steps Per AP 227
CVODE Benchmark Run Time 431.20 HH
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