Layer 5 Continuous Accommodating Untufted Pyramidal Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000697
cADpyr232_L5_UTPC_34f655e7f8_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000697
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.43 mV
Rheobase Current Interval (0.07553, 0.07805] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0413 nA
Testing Temperature 34.0 °C
Stability Interval [-3.75, 15.0] nA
AP 1-2 Amplitude Drop 2.0094 mV
AP 1 Steady State Amplitude Change 2.1878 mV
AP 1 Amplitude 81.1673 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 17.2300 ms
AP 1 Rate of Change Peak to Trough -5.2075 mV/ms
AP 1 AHP Depth 8.5573 mV
AP2 Amplitude 79.1580 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 28.6900 ms
AP 2 Rate of Change Peak to Trough -3.1707 mV/ms
AP 2 AHP Depth 11.8101 mV
AP 1-2 Amplitude Change Percent -2.4756 %
AP 1-2 Half Width Change Percent -1.5625 %
AP 1-2 Rate of Change Peak to Trough Percent Change -39.1120 %
AP 1-2 AHP Depth Percent Change 38.0114 %
Input Resistance 181.1392 MΩ
AP 1 Delay Mean 48.6000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 122.9300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 123.1950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1130 %/ms
Accommodation at Steady State Mean -56.5187 %
Accommodation Rate Mean at Steady State 5.2833 ms
ISI CV 5.7657
ISI Median 170.2900 ms
ISI Burst Mean Change 131.4812 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.1700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 36.5400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2086.0300 ms
Frequency Filter Type High-Pass
Frequency Filter Pass Above 31.6326 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5136.95 µm2
Number of Stems 7.0
Number of Bifurcations 45.0
Number of Branches 96.0
Overall Width 283.764 µm
Overall Height 715.919 µm
Overall Depth 223.48 µm
Average Diameter 0.536819 µm
Total Length 7912.57 µm
Total Surface 13275.1 µm2
Total Volume 3106.78 µm3
Max Euclidean Distance 656.517 µm
Max Path Distance 696.717 µm
Max Branch Order 16.0
Average Contraction 0.939465
Total Fragmentation 6339.0
Partition Asymmetry 0.602861
Average Rall's Ratio 2.69935
Average Bifurcation Angle Local 59.7915 °
Average Bifurcation Angle Remote 60.2604 °
Fractal Dimension 1.01401
Complexity Summary
State Equations 1725
Optimal Time-Step 0.00756 ms
Relative Complexity 443.65 HH
Model Size
Sections 98
Compartments 400
State Equations 1725
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00756 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 443.65 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.55 %
Max. Stable Time-Step Benchmark Run Time 837.78 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18688 Hz
CVODE Steps Per AP 81
CVODE Benchmark Run Time 429.83 HH
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