Layer 5 Continuous Accommodating Thick-tufted Pyramidal Cell with an early bifurcating apical tuft (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Thick-tufted, pyramidal, bifurcating apical tuft, rat, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000695
cADpyr232_L5_TTPC2_a467781f53_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000695
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.86 mV
Rheobase Current Interval (0.22659, 0.23415] nA
Threshold Current Interval (1.87500, 1.93359] nA
Bias Current (to -80.00 mV) -0.1753 nA
Testing Temperature 34.0 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 1.7023 mV
AP 1 Steady State Amplitude Change 2.3018 mV
AP 1 Amplitude 84.9495 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 15.3800 ms
AP 1 Rate of Change Peak to Trough -6.0676 mV/ms
AP 1 AHP Depth 8.3698 mV
AP2 Amplitude 83.2471 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 23.7300 ms
AP 2 Rate of Change Peak to Trough -3.9770 mV/ms
AP 2 AHP Depth 11.1276 mV
AP 1-2 Amplitude Change Percent -2.0039 %
AP 1-2 Half Width Change Percent -2.9851 %
AP 1-2 Rate of Change Peak to Trough Percent Change -34.4544 %
AP 1-2 AHP Depth Percent Change 32.9505 %
Input Resistance 51.8712 MΩ
AP 1 Delay Mean 42.1900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 117.4600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 124.5500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1144 %/ms
Accommodation at Steady State Mean -57.9415 %
Accommodation Rate Mean at Steady State 55.8469 ms
ISI CV 5.6701
ISI Median 177.1400 ms
ISI Burst Mean Change 130.9419 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 13.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 39.4600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 40.6350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2063.7300 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5071 Hz
Frequency Filter Pass Below 93.6359 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 25771.4 µm2
Number of Stems 10.0
Number of Bifurcations 91.0
Number of Branches 191.0
Overall Width 301.091 µm
Overall Height 1285.57 µm
Overall Depth 266.4 µm
Average Diameter 1.00872 µm
Total Length 15442.6 µm
Total Surface 48714.7 µm2
Total Volume 20413.9 µm3
Max Euclidean Distance 1173.28 µm
Max Path Distance 1234.18 µm
Max Branch Order 20.0
Average Contraction 0.963786
Total Fragmentation 5589.0
Partition Asymmetry 0.431257
Average Rall's Ratio 2.59312
Average Bifurcation Angle Local 50.9595 °
Average Bifurcation Angle Remote 52.6677 °
Fractal Dimension 1.00737
Complexity Summary
State Equations 3297
Optimal Time-Step 0.00760 ms
Relative Complexity 910.41 HH
Model Size
Sections 192
Compartments 780
State Equations 3297
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00760 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 910.41 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.60 %
Max. Stable Time-Step Benchmark Run Time 1728.17 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15832 Hz
CVODE Steps Per AP 242
CVODE Benchmark Run Time 829.70 HH
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