Layer 5 Continuous Accommodating Thick-tufted Pyramidal Cell with an early bifurcating apical tuft (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Thick-tufted, pyramidal, bifurcating apical tuft, rat, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000694
cADpyr232_L5_TTPC2_a28017c6c7_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000694
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.79 mV
Rheobase Current Interval (0.22659, 0.23415] nA
Threshold Current Interval (1.87500, 1.93359] nA
Bias Current (to -80.00 mV) -0.1767 nA
Testing Temperature 34.0 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 1.7858 mV
AP 1 Steady State Amplitude Change 2.5106 mV
AP 1 Amplitude 85.4275 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 15.8300 ms
AP 1 Rate of Change Peak to Trough -5.9003 mV/ms
AP 1 AHP Depth 7.9748 mV
AP2 Amplitude 83.6417 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 23.3600 ms
AP 2 Rate of Change Peak to Trough -4.0443 mV/ms
AP 2 AHP Depth 10.8322 mV
AP 1-2 Amplitude Change Percent -2.0904 %
AP 1-2 Half Width Change Percent -1.5152 %
AP 1-2 Rate of Change Peak to Trough Percent Change -31.4571 %
AP 1-2 AHP Depth Percent Change 35.8308 %
Input Resistance 51.9887 MΩ
AP 1 Delay Mean 41.5000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 114.3500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 121.3800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1173 %/ms
Accommodation at Steady State Mean -58.6698 %
Accommodation Rate Mean at Steady State 58.5901 ms
ISI CV 5.5948
ISI Median 174.4300 ms
ISI Burst Mean Change 133.2327 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 13.6700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.6200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 39.1900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2058.7400 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5046 Hz
Frequency Filter Pass Below 134.0963 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 25771.3 µm2
Number of Stems 10.0
Number of Bifurcations 91.0
Number of Branches 191.0
Overall Width 313.031 µm
Overall Height 1292.19 µm
Overall Depth 253.33 µm
Average Diameter 1.00913 µm
Total Length 15565.6 µm
Total Surface 49130.8 µm2
Total Volume 20547.4 µm3
Max Euclidean Distance 1166.87 µm
Max Path Distance 1249.71 µm
Max Branch Order 20.0
Average Contraction 0.963584
Total Fragmentation 5589.0
Partition Asymmetry 0.431257
Average Rall's Ratio 2.59312
Average Bifurcation Angle Local 49.6348 °
Average Bifurcation Angle Remote 52.2737 °
Fractal Dimension 1.00734
Complexity Summary
State Equations 3337
Optimal Time-Step 0.01153 ms
Relative Complexity 516.72 HH
Model Size
Sections 192
Compartments 784
State Equations 3337
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.01153 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 516.72 HH
 
Maximum Stable Time-Step 0.125 ms
Maximum Stable Time-Step Error 1.98 %
Max. Stable Time-Step Benchmark Run Time 744.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15824 Hz
CVODE Steps Per AP 242
CVODE Benchmark Run Time 714.48 HH
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