Layer 5 Continuous Accommodating Thick-tufted Pyramidal Cell with a late bifurcating apical tuft (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,rat, somatosensory cortex, thick-tufted, pyramidal, bifurcating apical tuft, rat, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000689
cADpyr232_L5_TTPC1_da1088139b_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000689
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.34 mV
Rheobase Current Interval (0.21240, 0.21904] nA
Threshold Current Interval (1.64062, 1.69922] nA
Bias Current (to -80.00 mV) -0.1536 nA
Testing Temperature 34.0 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 1.8019 mV
AP 1 Steady State Amplitude Change 2.6047 mV
AP 1 Amplitude 85.3813 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 15.7200 ms
AP 1 Rate of Change Peak to Trough -5.8599 mV/ms
AP 1 AHP Depth 6.7368 mV
AP2 Amplitude 83.5794 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 26.2300 ms
AP 2 Rate of Change Peak to Trough -3.5469 mV/ms
AP 2 AHP Depth 9.4570 mV
AP 1-2 Amplitude Change Percent -2.1104 %
AP 1-2 Half Width Change Percent -1.4706 %
AP 1-2 Rate of Change Peak to Trough Percent Change -39.4712 %
AP 1-2 AHP Depth Percent Change 40.3781 %
Input Resistance 56.0628 MΩ
AP 1 Delay Mean 45.2800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 116.6700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 120.3850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1165 %/ms
Accommodation at Steady State Mean -59.1602 %
Accommodation Rate Mean at Steady State 5.3177 ms
ISI CV 5.5294
ISI Median 173.4500 ms
ISI Burst Mean Change 137.2601 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.3100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.8000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.9600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2076.8100 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.0067 Hz
Frequency Filter Pass Below 138.5898 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 19886.4 µm2
Number of Stems 12.0
Number of Bifurcations 114.0
Number of Branches 239.0
Overall Width 370.137 µm
Overall Height 1207.14 µm
Overall Depth 202.65 µm
Average Diameter 0.867848 µm
Total Length 18412.2 µm
Total Surface 48256.7 µm2
Total Volume 16753.2 µm3
Max Euclidean Distance 1088.68 µm
Max Path Distance 1194.01 µm
Max Branch Order 23.0
Average Contraction 0.956789
Total Fragmentation 7930.0
Partition Asymmetry 0.500308
Average Rall's Ratio 2.02549
Average Bifurcation Angle Local 58.2762 °
Average Bifurcation Angle Remote 55.7829 °
Fractal Dimension 1.00933
Complexity Summary
State Equations 3939
Optimal Time-Step 0.00759 ms
Relative Complexity 1215.73 HH
Model Size
Sections 239
Compartments 913
State Equations 3939
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00759 ms
Optimal Time-Step Error 0.11 %
Optimal Time-Step Benchmark Run Time 1215.73 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.42 %
Max. Stable Time-Step Benchmark Run Time 2305.85 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15748 Hz
CVODE Steps Per AP 322
CVODE Benchmark Run Time 1150.59 HH
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