Layer 5 Continuous Accommodating Thick-tufted Pyramidal Cell with a late bifurcating apical tuft (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,rat, somatosensory cortex, thick-tufted, pyramidal, bifurcating apical tuft, rat, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000688
cADpyr232_L5_TTPC1_b6836fcf6f_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000688
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.22 mV
Rheobase Current Interval (0.15930, 0.16479] nA
Threshold Current Interval (1.34766, 1.40625] nA
Bias Current (to -80.00 mV) -0.1212 nA
Testing Temperature 34.0 °C
Stability Interval [-9.0625, 15.0] nA
AP 1-2 Amplitude Drop 1.4185 mV
AP 1 Steady State Amplitude Change 1.9165 mV
AP 1 Amplitude 85.6184 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 15.7500 ms
AP 1 Rate of Change Peak to Trough -5.9898 mV/ms
AP 1 AHP Depth 8.7208 mV
AP2 Amplitude 84.1999 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 25.0500 ms
AP 2 Rate of Change Peak to Trough -3.8228 mV/ms
AP 2 AHP Depth 11.5606 mV
AP 1-2 Amplitude Change Percent -1.6567 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -36.1785 %
AP 1-2 AHP Depth Percent Change 32.5632 %
Input Resistance 72.7267 MΩ
AP 1 Delay Mean 43.5800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 131.0700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 139.5050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1033 %/ms
Accommodation at Steady State Mean -54.4024 %
Accommodation Rate Mean at Steady State 33.1600 ms
ISI CV 5.7765
ISI Median 190.8800 ms
ISI Burst Mean Change 118.9050 %
Spike Rate (Strong Stimulation) 10.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.2200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 42.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 49.6300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2081.9000 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 49.3263 Hz
Frequency Filter Pass Below 86.2210 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 19431.7 µm2
Number of Stems 9.0
Number of Bifurcations 115.0
Number of Branches 238.0
Overall Width 347.554 µm
Overall Height 1358.65 µm
Overall Depth 269.05 µm
Average Diameter 0.822354 µm
Total Length 15492.8 µm
Total Surface 36610.3 µm2
Total Volume 13524.4 µm3
Max Euclidean Distance 1255.01 µm
Max Path Distance 1366.65 µm
Max Branch Order 23.0
Average Contraction 0.982802
Total Fragmentation 3088.0
Partition Asymmetry 0.499814
Average Rall's Ratio 1.30537
Average Bifurcation Angle Local 60.5412 °
Average Bifurcation Angle Remote 62.4005 °
Fractal Dimension 1.00305
Complexity Summary
State Equations 3757
Optimal Time-Step 0.00783 ms
Relative Complexity 959.33 HH
Model Size
Sections 236
Compartments 792
State Equations 3757
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00783 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 959.33 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.50 %
Max. Stable Time-Step Benchmark Run Time 1877.41 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15282 Hz
CVODE Steps Per AP 431
CVODE Benchmark Run Time 967.69 HH
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