Layer 5 Continuous Accommodating Thick-tufted Pyramidal Cell with a late bifurcating apical tuft (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,rat, somatosensory cortex, thick-tufted, pyramidal, bifurcating apical tuft, rat, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000687
cADpyr232_L5_TTPC1_0fb1ca4724_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000687
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.35 mV
Rheobase Current Interval (0.21286, 0.21973] nA
Threshold Current Interval (1.69922, 1.75781] nA
Bias Current (to -80.00 mV) -0.1541 nA
Testing Temperature 34.0 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 1.7213 mV
AP 1 Steady State Amplitude Change 2.5750 mV
AP 1 Amplitude 85.1628 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 15.4000 ms
AP 1 Rate of Change Peak to Trough -6.0101 mV/ms
AP 1 AHP Depth 7.3920 mV
AP2 Amplitude 83.4414 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 25.4600 ms
AP 2 Rate of Change Peak to Trough -3.6720 mV/ms
AP 2 AHP Depth 10.0480 mV
AP 1-2 Amplitude Change Percent -2.0212 %
AP 1-2 Half Width Change Percent -1.4925 %
AP 1-2 Rate of Change Peak to Trough Percent Change -38.9021 %
AP 1-2 AHP Depth Percent Change 35.9303 %
Input Resistance 55.9355 MΩ
AP 1 Delay Mean 45.2800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 117.4500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 120.3850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1165 %/ms
Accommodation at Steady State Mean -58.8650 %
Accommodation Rate Mean at Steady State 59.5849 ms
ISI CV 5.5723
ISI Median 173.5100 ms
ISI Burst Mean Change 133.6151 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.3400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 39.3300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.5750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2074.1100 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5055 Hz
Frequency Filter Pass Below 139.7401 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 19886.4 µm2
Number of Stems 12.0
Number of Bifurcations 114.0
Number of Branches 239.0
Overall Width 370.14 µm
Overall Height 1207.12 µm
Overall Depth 202.64 µm
Average Diameter 0.867713 µm
Total Length 18412.6 µm
Total Surface 48273.6 µm2
Total Volume 16766.1 µm3
Max Euclidean Distance 1088.68 µm
Max Path Distance 1194.0 µm
Max Branch Order 23.0
Average Contraction 0.956832
Total Fragmentation 7925.0
Partition Asymmetry 0.500308
Average Rall's Ratio 2.02549
Average Bifurcation Angle Local 58.2041 °
Average Bifurcation Angle Remote 55.7625 °
Fractal Dimension 1.00933
Complexity Summary
State Equations 3939
Optimal Time-Step 0.00753 ms
Relative Complexity 1202.89 HH
Model Size
Sections 239
Compartments 913
State Equations 3939
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00753 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 1202.89 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.50 %
Max. Stable Time-Step Benchmark Run Time 2264.06 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15931 Hz
CVODE Steps Per AP 285
CVODE Benchmark Run Time 1118.83 HH
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