Layer 5 Continuous Accommodating Slender-tufted Pyramidal Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Slender-tufted, pyramidal, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000686
cADpyr232_L5_STPC_d63221b7a8_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000686
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.70 mV
Rheobase Current Interval (0.09819, 0.10117] nA
Threshold Current Interval (0.70312, 0.76172] nA
Bias Current (to -80.00 mV) -0.0556 nA
Testing Temperature 34.0 °C
Stability Interval [-5.0, 15.0] nA
AP 1-2 Amplitude Drop 1.9372 mV
AP 1 Steady State Amplitude Change 3.0699 mV
AP 1 Amplitude 90.0496 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 2.6400 ms
AP 1 Rate of Change Peak to Trough -36.2919 mV/ms
AP 1 AHP Depth 5.7611 mV
AP2 Amplitude 88.1124 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 30.3000 ms
AP 2 Rate of Change Peak to Trough -3.1869 mV/ms
AP 2 AHP Depth 8.4502 mV
AP 1-2 Amplitude Change Percent -2.1513 %
AP 1-2 Half Width Change Percent -1.4925 %
AP 1-2 Rate of Change Peak to Trough Percent Change -91.2188 %
AP 1-2 AHP Depth Percent Change 46.6767 %
Input Resistance 129.9857 MΩ
AP 1 Delay Mean 45.3800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 121.4800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 128.4850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1102 %/ms
Accommodation at Steady State Mean -57.8652 %
Accommodation Rate Mean at Steady State 3.0323 ms
ISI CV 5.6702
ISI Median 179.3800 ms
ISI Burst Mean Change 137.6741 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.1900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 41.8300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 46.8650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2077.2700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7874.61 µm2
Number of Stems 10.0
Number of Bifurcations 48.0
Number of Branches 105.0
Overall Width 369.379 µm
Overall Height 921.62 µm
Overall Depth 285.0 µm
Average Diameter 0.513163 µm
Total Length 11987.1 µm
Total Surface 19309.4 µm2
Total Volume 4506.56 µm3
Max Euclidean Distance 894.757 µm
Max Path Distance 1007.3 µm
Max Branch Order 20.0
Average Contraction 0.923673
Total Fragmentation 8960.0
Partition Asymmetry 0.59018
Average Rall's Ratio 2.31967
Average Bifurcation Angle Local 67.9135 °
Average Bifurcation Angle Remote 62.1523 °
Fractal Dimension 1.0169
Complexity Summary
State Equations 2507
Optimal Time-Step 0.00754 ms
Relative Complexity 715.69 HH
Model Size
Sections 103
Compartments 607
State Equations 2507
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00754 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 715.69 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.51 %
Max. Stable Time-Step Benchmark Run Time 1348.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16668 Hz
CVODE Steps Per AP 391
CVODE Benchmark Run Time 730.35 HH
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