Layer 5 Continuous Accommodating Slender-tufted Pyramidal Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Slender-tufted, pyramidal, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000685
cADpyr232_L5_STPC_d16b0be14e_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000685
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.28 mV
Rheobase Current Interval (0.16479, 0.16937] nA
Threshold Current Interval (1.11328, 1.17188] nA
Bias Current (to -80.00 mV) -0.1480 nA
Testing Temperature 34.0 °C
Stability Interval [-8.4375, 15.0] nA
AP 1-2 Amplitude Drop 2.2920 mV
AP 1 Steady State Amplitude Change 2.7520 mV
AP 1 Amplitude 86.5804 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 24.7200 ms
AP 1 Rate of Change Peak to Trough -3.6891 mV/ms
AP 1 AHP Depth 4.6136 mV
AP2 Amplitude 84.2884 mV
AP2 Width at Half Height 0.7100 ms
AP 2 Width (Peak to Trough) 37.7500 ms
AP 2 Rate of Change Peak to Trough -2.4607 mV/ms
AP 2 AHP Depth 8.6020 mV
AP 1-2 Amplitude Change Percent -2.6473 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -33.2984 %
AP 1-2 AHP Depth Percent Change 86.4491 %
Input Resistance 66.9087 MΩ
AP 1 Delay Mean 36.9600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 113.3800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 132.3050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -58.8906 %
Accommodation Rate Mean at Steady State 3.6983 ms
ISI CV 5.5706
ISI Median 184.5200 ms
ISI Burst Mean Change 146.2575 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.6100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.0100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 42.8150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2069.0800 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.0076 Hz
Frequency Filter Pass Below 128.7630 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 17483.1 µm2
Number of Stems 7.0
Number of Bifurcations 99.0
Number of Branches 204.0
Overall Width 338.165 µm
Overall Height 1199.71 µm
Overall Depth 347.89 µm
Average Diameter 0.940274 µm
Total Length 12556.0 µm
Total Surface 33142.1 µm2
Total Volume 14943.8 µm3
Max Euclidean Distance 1060.36 µm
Max Path Distance 1364.77 µm
Max Branch Order 25.0
Average Contraction 0.976522
Total Fragmentation 2081.0
Partition Asymmetry 0.487602
Average Rall's Ratio 0.998971
Average Bifurcation Angle Local 61.0983 °
Average Bifurcation Angle Remote 61.5044 °
Fractal Dimension 1.00516
Complexity Summary
State Equations 3309
Optimal Time-Step 0.00759 ms
Relative Complexity 998.78 HH
Model Size
Sections 206
Compartments 638
State Equations 3309
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00759 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 998.78 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.26 %
Max. Stable Time-Step Benchmark Run Time 1894.12 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15436 Hz
CVODE Steps Per AP 487
CVODE Benchmark Run Time 1011.67 HH
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