Layer 5 Continuous Accommodating Slender-tufted Pyramidal Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 5,Slender-tufted, pyramidal, rat, somatosensory cortex, neocortex, biophysical, continuous accommodating slender-tufted pyramidal cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000684
cADpyr232_L5_STPC_a78c3cbca8_0_0.cell.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH001436
Ca_HVA.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000684
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.35 mV
Rheobase Current Interval (0.12794, 0.13092] nA
Threshold Current Interval (0.70312, 0.76172] nA
Bias Current (to -80.00 mV) -0.0525 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 3.1297 mV
AP 1 Steady State Amplitude Change 2.6008 mV
AP 1 Amplitude 84.9353 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 3.2000 ms
AP 1 Rate of Change Peak to Trough -30.3101 mV/ms
AP 1 AHP Depth 12.0570 mV
AP2 Amplitude 81.8056 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 3.3100 ms
AP 2 Rate of Change Peak to Trough -28.6285 mV/ms
AP 2 AHP Depth 12.9547 mV
AP 1-2 Amplitude Change Percent -3.6848 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.5480 %
AP 1-2 AHP Depth Percent Change 7.4456 %
Input Resistance 142.1682 MΩ
AP 1 Delay Mean 49.1100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 134.4200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 112.2600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -0.7743 %
Accommodation Rate Mean at Steady State 24.4838 ms
ISI CV 10.6957
ISI Median 130.6500 ms
ISI Burst Mean Change 63.1813 %
Spike Rate (Strong Stimulation) 18.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.8400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.4500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.9800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2108.2400 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.0086 Hz
Frequency Filter Pass Below 127.9140 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 12305.7 µm2
Number of Stems 7.0
Number of Bifurcations 64.0
Number of Branches 134.0
Overall Width 501.576 µm
Overall Height 1437.14 µm
Overall Depth 474.94 µm
Average Diameter 0.521554 µm
Total Length 12462.3 µm
Total Surface 19290.5 µm2
Total Volume 5658.06 µm3
Max Euclidean Distance 1265.61 µm
Max Path Distance 1379.97 µm
Max Branch Order 21.0
Average Contraction 0.938878
Total Fragmentation 7176.0
Partition Asymmetry 0.507789
Average Rall's Ratio 2.19
Average Bifurcation Angle Local 61.5496 °
Average Bifurcation Angle Remote 57.1714 °
Fractal Dimension 1.0131
Complexity Summary
Relative Complexity 737.32 HH
State Equations 2863
Optimal Time-Step 0.00775 ms
Model Size
Sections 135
Compartments 633
State Equations 2863
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18443 Hz
CVODE Steps Per AP 225
CVODE Benchmark Run Time 737.32 HH
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