Layer 6 Continuous Accommodating Untufted Pyramidal Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000681
cADpyr231_L6_UTPC_9f3da79327_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000681
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.48 mV
Rheobase Current Interval (0.09613, 0.09842] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0362 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 4.4791 mV
AP 1 Steady State Amplitude Change 5.6851 mV
AP 1 Amplitude 84.7453 mV
AP 1 Width at Half Height 0.8400 ms
AP 1 Width (Peak To Trough) 13.9000 ms
AP 1 Rate of Change Peak to Trough -6.4409 mV/ms
AP 1 AHP Depth 4.7833 mV
AP2 Amplitude 80.2662 mV
AP2 Width at Half Height 0.8400 ms
AP 2 Width (Peak to Trough) 15.8300 ms
AP 2 Rate of Change Peak to Trough -5.5600 mV/ms
AP 2 AHP Depth 7.7492 mV
AP 1-2 Amplitude Change Percent -5.2854 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.6762 %
AP 1-2 AHP Depth Percent Change 62.0062 %
Input Resistance 198.9176 MΩ
AP 1 Delay Mean 23.7200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 64.8500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 54.9900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0827 %/ms
Accommodation at Steady State Mean -89.7880 %
Accommodation Rate Mean at Steady State 190.7543 ms
ISI CV 2.5083
ISI Median 244.3400 ms
ISI Burst Mean Change 67.3961 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.4200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.2600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.4650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2016.6900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5487.29 µm2
Number of Stems 7.0
Number of Bifurcations 42.0
Number of Branches 90.0
Overall Width 338.438 µm
Overall Height 794.428 µm
Overall Depth 247.75 µm
Average Diameter 0.585016 µm
Total Length 7028.16 µm
Total Surface 12191.0 µm2
Total Volume 3156.16 µm3
Max Euclidean Distance 947.743 µm
Max Path Distance 989.373 µm
Max Branch Order 13.0
Average Contraction 0.935507
Total Fragmentation 4234.0
Partition Asymmetry 0.510172
Average Rall's Ratio 2.46029
Average Bifurcation Angle Local 55.1599 °
Average Bifurcation Angle Remote 59.1434 °
Fractal Dimension 1.01318
Complexity Summary
State Equations 1639
Optimal Time-Step 0.00743 ms
Relative Complexity 379.83 HH
Model Size
Sections 91
Compartments 351
State Equations 1639
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00743 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 379.83 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.13 %
Max. Stable Time-Step Benchmark Run Time 705.21 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17628 Hz
CVODE Steps Per AP 410
CVODE Benchmark Run Time 403.18 HH
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