Layer 6 Continuous Accommodating Untufted Pyramidal Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000680
cADpyr231_L6_UTPC_9d28264fcd_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000680
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.84 mV
Rheobase Current Interval (0.08057, 0.08240] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0312 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 4.0639 mV
AP 1 Steady State Amplitude Change 3.2910 mV
AP 1 Amplitude 84.2830 mV
AP 1 Width at Half Height 0.9000 ms
AP 1 Width (Peak To Trough) 7.4600 ms
AP 1 Rate of Change Peak to Trough -11.9549 mV/ms
AP 1 AHP Depth 4.9009 mV
AP2 Amplitude 80.2190 mV
AP2 Width at Half Height 0.9000 ms
AP 2 Width (Peak to Trough) 14.9100 ms
AP 2 Rate of Change Peak to Trough -5.8470 mV/ms
AP 2 AHP Depth 6.9592 mV
AP 1-2 Amplitude Change Percent -4.8218 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -51.0917 %
AP 1-2 AHP Depth Percent Change 41.9977 %
Input Resistance 221.1517 MΩ
AP 1 Delay Mean 31.8100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 74.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 62.7400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0774 %/ms
Accommodation at Steady State Mean -88.9455 %
Accommodation Rate Mean at Steady State 208.2914 ms
ISI CV 2.5843
ISI Median 257.3700 ms
ISI Burst Mean Change 94.6232 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.1500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.1600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 21.5050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2052.1700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 132.3072 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4504.35 µm2
Number of Stems 10.0
Number of Bifurcations 32.0
Number of Branches 73.0
Overall Width 570.028 µm
Overall Height 1275.63 µm
Overall Depth 264.44 µm
Average Diameter 0.399387 µm
Total Length 9704.31 µm
Total Surface 11273.6 µm2
Total Volume 2476.83 µm3
Max Euclidean Distance 1095.78 µm
Max Path Distance 1198.23 µm
Max Branch Order 11.0
Average Contraction 0.958635
Total Fragmentation 3337.0
Partition Asymmetry 0.526488
Average Rall's Ratio 1.19136
Average Bifurcation Angle Local 67.6665 °
Average Bifurcation Angle Remote 62.5909 °
Fractal Dimension 1.00673
Complexity Summary
State Equations 1833
Optimal Time-Step 0.00757 ms
Relative Complexity 426.56 HH
Model Size
Sections 74
Compartments 492
State Equations 1833
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00757 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 426.56 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 807.00 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17149 Hz
CVODE Steps Per AP 310
CVODE Benchmark Run Time 430.03 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS