Layer 6 Continuous Accommodating Untufted Pyramidal Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Untufted, pyramidal, rat, neocortex, somatosensory cortex, biophysical, continuous accommodating untufted pyramidal cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000679
cADpyr231_L6_UTPC_295f0e6025_0_0.cell.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH001436
Ca_HVA.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000679
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.19 mV
Rheobase Current Interval (0.12817, 0.13138] nA
Threshold Current Interval (0.76172, 0.82031] nA
Bias Current (to -80.00 mV) -0.0544 nA
Testing Temperature 34.0 °C
Stability Interval [-5.0, 15.0] nA
AP 1-2 Amplitude Drop -0.4591 mV
AP 1 Steady State Amplitude Change 4.1120 mV
AP 1 Amplitude 68.0143 mV
AP 1 Width at Half Height 1.0100 ms
AP 1 Width (Peak To Trough) 21.0200 ms
AP 1 Rate of Change Peak to Trough -3.6073 mV/ms
AP 1 AHP Depth 7.8108 mV
AP2 Amplitude 68.4734 mV
AP2 Width at Half Height 1.0000 ms
AP 2 Width (Peak to Trough) 23.5500 ms
AP 2 Rate of Change Peak to Trough -3.3921 mV/ms
AP 2 AHP Depth 11.4098 mV
AP 1-2 Amplitude Change Percent 0.6750 %
AP 1-2 Half Width Change Percent -0.9901 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.9660 %
AP 1-2 AHP Depth Percent Change 46.0783 %
Input Resistance 138.7415 MΩ
AP 1 Delay Mean 35.3400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 87.1900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 86.0200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0451 %/ms
Accommodation at Steady State Mean -85.2709 %
Accommodation Rate Mean at Steady State 244.6037 ms
ISI CV 2.6620
ISI Median 283.0000 ms
ISI Burst Mean Change 131.8033 %
Spike Rate (Strong Stimulation) 7.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.5100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.8200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2059.9700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6192.62 µm2
Number of Stems 9.0
Number of Bifurcations 39.0
Number of Branches 86.0
Overall Width 270.012 µm
Overall Height 969.979 µm
Overall Depth 245.37 µm
Average Diameter 0.581044 µm
Total Length 8634.93 µm
Total Surface 15985.3 µm2
Total Volume 4980.56 µm3
Max Euclidean Distance 1028.96 µm
Max Path Distance 1111.01 µm
Max Branch Order 13.0
Average Contraction 0.930895
Total Fragmentation 7255.0
Partition Asymmetry 0.669132
Average Rall's Ratio 1.4182
Average Bifurcation Angle Local 67.0274 °
Average Bifurcation Angle Remote 62.6043 °
Fractal Dimension 1.01289
Complexity Summary
Relative Complexity 464.40 HH
State Equations 1827
Optimal Time-Step 0.00792 ms
Model Size
Sections 87
Compartments 437
State Equations 1827
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18076 Hz
CVODE Steps Per AP 273
CVODE Benchmark Run Time 464.40 HH
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